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Aldo-Keto Reductase Family 1 Member C3

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Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

research Steroidogenesis of the Testis: New Genes and Pathways

70 citations , April 2014 in “Annales d'endocrinologie”

New genes and pathways are important for testosterone production and male sexual development.

research Aldo-Keto Reductase (AKR) 1C3 Inhibitors: A Patent Review

70 citations , September 2017 in “Expert opinion on therapeutic patents”

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

research Pre-Receptor Regulation of the Androgen Receptor

56 citations , November 2007 in “Molecular and cellular endocrinology”

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

research Novel Aldo-Keto Reductase 1C3 Inhibitor Affects Androgen Metabolism but Not Ovarian Function in Healthy Women: A Phase 1 Study

8 citations , June 2023 in “European Journal of Endocrinology”

The inhibitor affects androgen metabolism but not ovarian function.

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community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 1 year ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community Switched from finasteride to dutasteride - 2 month update

in Finasteride/Dutasteride 6 upvotes 2 years ago

The user switched from finasteride to dutasteride for hair loss treatment, but experienced increased libido, itchy scalp, and accelerated hair loss. Another user suggested that genetic variations might cause dutasteride to be less effective and recommended checking for specific genetic markers.

community what's an effective natural dht blocker other than fin?

in Chat 6 upvotes 4 years ago

Curcumin, found in turmeric, may reduce DHT levels and hair loss, similar to finasteride, but without its side effects. However, natural DHT blockers are generally considered too weak to make a significant difference in hair loss.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 444 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community The theory that explains everything. Please help me make this big!

in Research/Science 2446 upvotes 4 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

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