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research Stability Study of Finasteride: Stability-Indicating LC Method, In Silico and LC–ESI-MS Analysis of Major Degradation Product, and an In Vitro Biological Safety Study
Finasteride's stability and safety confirmed through precise analytical methods.
research The Oxidative Degradation of Keratin (Wool and Bovine Hair)
Oxidizing agents break down keratin in wool and hair, causing swelling and increased solubility.
research Isolation and Structural Characterization of Finasteride Degradation Products by Preparative HPLC, HRMS, and NMR
This study investigates the degradation profile of finasteride, a drug used for benign prostatic hyperplasia and androgenetic alopecia, under stress conditions. Using LC–MS, three degradation products were identified under acidic conditions, with minimal degradation in alkaline and oxidative environments. The degradation products were isolated and analyzed using preparative HPLC, HRMS, and NMR spectroscopy. The study revealed that the degradation process of DP-1 involved cleavage of the tert-butyl amide and addition of water across the alkene moiety. The structure of DP-1 was established through various spectroscopic techniques, and it, along with other degradation products, was found to be previously undescribed. These findings enhance the understanding of finasteride's degradation chemistry, aiding impurity profiling, stability studies, and quality control of its formulations.
research A Stability Indicating UPLC Method for Finasteride and Its Related Impurities
A new method effectively analyzes Finasteride and its impurities, even under stress conditions.
research Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice
Baicalin helps hair growth by activating specific cell signals and pathways.
Community Join
5 / 1000+ resultscommunity What should I include in my blood test?
The user has been using finasteride, dutasteride, and minoxidil without success and is considering a comprehensive blood test to explore other causes of hair loss. They are unsure about the necessity and cost of the extensive tests and are seeking advice on whether to proceed with the full panel or focus on specific tests.
community Blood work, is it worth to pay for it?
The user is considering getting blood work to investigate the cause of ongoing hair loss despite using finasteride and dutasteride. Others suggest that while blood tests can provide useful health information, they may not change the hair treatment outcome.
community Dutasteride Users, do you Still Take Creatine?
The conversation discusses the potential impact of creatine on hair loss, with some users sharing personal experiences of increased shedding while others argue there's no scientific evidence linking creatine to hair loss. The original poster switched from finasteride to dutasteride and is considering resuming creatine after monitoring its effects on hair loss.
community Topical minoxidil brand (and form of application) matters. You can be a hyper-responder to one product and a non-responder to another.
Different minoxidil formulations affect hair growth and side effects. Higher propylene glycol and pH levels improve effectiveness but can cause scalp irritation.
community What are your thoughts on pre-finasteride blood work?
The user is considering resuming finasteride after a 6-month break and is debating the necessity of extensive blood work, including hormone and health markers, to establish a baseline. They are unsure if the tests are necessary since they experienced no side effects previously.