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GlossaryAlopecia Universalis

complete loss of all body and scalp hair

Alopecia Universalis (AU) is a severe form of alopecia areata characterized by the complete loss of hair on the scalp and body, including eyebrows and eyelashes. It is an autoimmune condition where the immune system mistakenly attacks hair follicles, leading to total hair loss.

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Research

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research Alopecia Universalis Associated with a Mutation in the Human hairless Gene

412 citations , January 1998 in “Science”

A mutation in the human hairless gene causes alopecia universalis.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations , June 2014 in “Journal of Investigative Dermatology”

A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.

research Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis

146 citations , July 2003 in “Journal of the American Academy of Dermatology”

Clobetasol propionate ointment can help some people with total hair loss regrow hair.

An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

research An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

130 citations , February 2018 in “Journal of Investigative Dermatology”

Tofacitinib may help treat severe hair loss, but more research is needed.

research Topical Ruxolitinib for the Treatment of Alopecia Universalis

96 citations , December 2015 in “JAMA dermatology”

Topical Ruxolitinib may safely treat severe hair loss.

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Community Join

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community Xeljanz medication for alopecia universalis?

in Treatment 5 upvotes 1 month ago

community Alopecia Areata Question

in Treatment 2 upvotes 5 years ago

A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

community No hair, don't care! [24/F] :)

60 upvotes 10 years ago

A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

community Olumiant alternative for Alopecia Areata?

in Treatment 1 upvotes 3 years ago

A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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