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research PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect

June 2025 in “Proceedings of the National Academy of Sciences”

A PIK3CA mutation in Schwann cells causes severe nerve damage and increased glycolysis, but early treatment can help.

research 899 HIF1A stabilisation in the ORS of human hair follicles promotes aerobic glycolysis and synthesis of angiogenic factors

April 2019 in “Journal of Investigative Dermatology”

Stabilizing HIF1A in hair follicles may boost hair growth by enhancing energy production and blood vessel formation.

research A Multidisciplinary Lifestyle Intervention for Women with Polycystic Ovary Syndrome: The Role of a Pulse-Based Diet and Aerobic Exercise on Reproductive, Cardio-Metabolic, and Quality of Life Outcomes

May 2018 in “University Library - University of Saskatchewan (University of Saskatchewan)”

A pulse-based diet with exercise improved PCOS health more than another diet, but benefits didn't last long-term.

research Metabolism of Freshly Isolated Human Hair Follicles Capable of Hair Elongation: A Glutaminolytic, Aerobic Glycolytic Tissue

71 citations , June 1993 in “Journal of Investigative Dermatology”

research The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate

33 citations , March 2018 in “Trends in cell biology”

Metabolism plays a key role in determining stem cell fate.

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community Cardio for more than 60 minutes reduces DHT levels and improve hair growth

in Research/Science 126 upvotes 1 year ago

Long aerobic exercise (over 60 minutes) can reduce DHT levels and improve hair health. Some users discuss using Tadalafil (Cialis) to further reduce DHT after exercise, while others mention using treatments like Minoxidil, Finasteride, and RU58841 for hair growth.

community + 5 years Finasteride and dermarroll journey PICS and ACTUAL DILEMMA

in Progress Pictures 54 upvotes 2 years ago

The user experienced improved hair density and thickness after using finasteride and dermarolling for 2.5 years but noticed hair loss when doing anaerobic exercise. They increased their finasteride dose and continued dermarolling but are considering not starting minoxidil due to its perceived hassle and uncertain long-term benefits.

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