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A Tale of Two Haplotypes: The EDA2R/AR Intergenic Region Is the Most Divergent Genomic Segment Between Africans and East Asians in the Human Genome

research A Tale of Two Haplotypes: The EDA2R/AR Intergenic Region is the Most Divergent Genomic Segment between Africans and East Asians in the Human Genome

4 citations , December 2012 in “Human Biology”

The most different genetic segment between Africans and East Asians is the EDA2R/AR region, with two main types influenced by population changes and natural selection, and linked to baldness.

research Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men

March 2025 in “Human Genetics and Genomics Advances”

Genetic predictions of baldness in Europeans don't apply well to African men.

research Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases

January 2012 in “Faculty of Health; Institute of Health and Biomedical Innovation”

Early-onset hair loss is linked to Parkinson's disease and decreased fertility.

research Pilot study: genetic distribution of AR, FGF5, SULT1A1 and CYP3A5 polymorphisms in male Mexican population with androgenetic alopecia.

January 2022 in “PubMed”

Certain genetic variations are linked to hair loss in Mexican men.

research HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond

30 citations , July 2019 in “Endocrinology”

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

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community Chromosome 20’s balding effects and why fin likely isn’t working for some.

in Treatment 96 upvotes 10 months ago

Finasteride is effective for DHT/AR-driven hair loss but not for chromosome 20-driven cases, where treatments like minoxidil, prostaglandin analogs, and low-level laser therapy may be more beneficial. Genetic testing can help determine the underlying cause of hair loss to tailor treatment effectively.

community My Theory Of Androgenic Alopecia

in Research/Science 20 upvotes 8 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

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Génésia - Maison des Soins Capillaires & du Bien-Être AncestralParis 15 Vaugirard · FR

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