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Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Androgen‐inducible TGF‐β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth

190 citations , October 2002 in “The FASEB journal”

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

research The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases?

34 citations , July 2020 in “Frontiers in immunology”

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

research Interaction between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen

4 citations , July 2006 in “British journal of dermatology/British journal of dermatology, Supplement”

Testosterone increases hair follicle cell growth when beard or axillary skin cells are present together.

research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factor(s) in Response to Testosterone Unlike Scalp Cells

51 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.

research Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

31 citations , April 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Androgens cause oil-producing skin cells with androgen receptors to mature and produce more oil.

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community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 2 years ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 3 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Fun thought experiment about halting hair loss permamently

in Research/Science 60 upvotes 2 years ago

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

community My Theory Of Androgenic Alopecia

in Research/Science 20 upvotes 8 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Is there any new drug that looks promising ?

in Research/Science 26 upvotes 2 years ago

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

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