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Did you mean Androgen Insensitivity Syndrome?

GlossaryAndrogen Insensitivity Syndrome

genetic condition causing resistance to male hormones in XY individuals

Androgen Insensitivity Syndrome (AIS) is a genetic condition where a person who is genetically male (with one X and one Y chromosome) is resistant to male hormones called androgens. As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man. This can lead to a range of physical manifestations, from completely typical female external genitalia to ambiguous genitalia, depending on the degree of insensitivity.

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research Graham Little-Piccardi-Lassueur syndrome associated with androgen insensitivity syndrome (testicular feminization)

22 citations , June 2004 in “Journal of The European Academy of Dermatology and Venereology”

A woman had both Graham Little-Piccardi-Lassueur syndrome, causing hair loss, and complete androgen insensitivity syndrome, making her genetically male but physically female. This suggests androgens don't affect the hair loss condition.

research Clinical, Hormonal, Behavioral, and Genetic Characteristics of Androgen Insensitivity Syndrome in a Brazilian Cohort: Five Novel Mutations in the Androgen Receptor Gene

174 citations , July 2003 in “The Journal of Clinical Endocrinology & Metabolism”

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

research Novel Missense Mutation in the P-Box of Androgen Receptor in a Patient with Androgen Insensitivity Syndrome

3 citations , January 2008 in “Endocrine journal”

A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.

research Identification of two additional novel mutations in the AR gene associated with severe forms of androgen insensitivity syndrome

1 citations , September 2019 in “Steroids”

Two new mutations in the AR gene linked to severe androgen insensitivity were found.

research Novel Androgen Receptor Gene Variant Containing a Premature Termination Codon in a Patient with Androgen Insensitivity Syndrome

1 citations , August 2019 in “Journal of pediatric & adolescent gynecology”

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

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community Fun thought experiment about halting hair loss permamently

in Research/Science 60 upvotes 2 years ago

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

community My Theory Of Androgenic Alopecia

in Research/Science 20 upvotes 8 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Neck tension, and hair loss, I am 100 percent sure that there is a connection

in Treatment 19 upvotes 2 years ago

The user believes neck tension and poor posture contribute to hair loss, noticing improvements with yoga and muscle relaxation. Replies suggest androgenic alopecia as the cause and recommend exercises.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 7 upvotes 2 years ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community My friend is so terrified of balding, he started microdosing estrogen…

in Treatment 1522 upvotes 7 months ago

A person is microdosing estrogen for hair loss after finasteride and dutasteride failed, risking feminizing effects. Alternatives like minoxidil, RU58841, or hair transplants are suggested.

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