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GlossaryAndrogen Receptor Gene

encodes a protein that binds male hormones like testosterone

The Androgen Receptor Gene (AR Gene) is a gene located on the X chromosome that encodes the androgen receptor, a protein that binds to androgens, which are male hormones like testosterone. This receptor plays a crucial role in the development and maintenance of male characteristics, and mutations in the AR gene can lead to conditions such as androgen insensitivity syndrome and contribute to hair loss disorders like androgenetic alopecia.

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Research

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research Decreased Androgen Receptor Gene Methylation in Premature Pubarche: A Novel Pathogenetic Mechanism?

53 citations , January 2006 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Reduced AR gene methylation may cause early pubic hair growth in girls.

research Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome

44 citations , January 2008 in “Fertility and Sterility”

Longer CAG repeat lengths in the androgen receptor gene are linked to higher testosterone levels in women with PCOS.

research Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis

41 citations , October 2011 in “Clinical and Experimental Dermatology”

G allele of AR Stul polymorphism linked to higher hair loss risk, especially in white people.

research No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene

40 citations , January 2013 in “Frontiers in Endocrinology”

Finger length ratios are not linked to the number of specific gene repeats affecting testosterone sensitivity.

research Polymorphisms in androgen and estrogen receptor genes: effects on male aging

12 citations , October 2004 in “Experimental Gerontology”

Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

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community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community The closest thing to a cure before hair cloning or genetic via?

in Treatment 9 upvotes 3 years ago

The conversation discusses using finasteride or dutasteride to reduce DHT, CosmeRNA to target androgen receptors, and Minoxidil as a vasodilator for hair growth. The regimen aims to maintain hair by addressing DHT-AR ratio and continuous Minoxidil use.

community Fun thought experiment about halting hair loss permamently

in Research/Science 60 upvotes 2 years ago

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 2 years ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 3 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

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