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The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

72 citations , January 2003 in “American Journal of Pathology”

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

research Lack of androgen receptor transcriptional activity in human keratinocytes

30 citations , June 2000 in “Journal of dermatological science”

Human keratinocytes do not naturally respond to androgens.

research Modulation of Androgen Receptor Transcriptional Activity

February 2009 in “RePub (Erasmus University Rotterdam)”

Androgen receptor activity is influenced by hormones, co-factors, modifications, and mutations.

research Mechanisms that regulate androgen receptor transcriptional activity

August 2019 in “Carolina Digital Repository (University of North Carolina at Chapel Hill)”

DHT enhances androgen receptor activity more than testosterone, and MAGE-11 influences this activity through specific interactions.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ

11 citations , July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

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community Minoxidil is a 5ar inhibitor according to research

in Research/Science 148 upvotes 9 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 94 upvotes 6 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Breezula phase 3 results said to be released next month

in Product 27 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community GT20029 Will Replace Finasteride For Hair Loss

in Research/Science 50 upvotes 2 months ago

GT20029 shows promise as a topical treatment for hair loss, potentially replacing finasteride for some due to its low systemic exposure and ability to degrade androgen receptors. However, skepticism remains about its long-term efficacy and availability, with some users expressing doubt about new treatments consistently failing to reach the market.

community Research: Minoxidil grows hair by suppressing androgen activity (DHT) in hair follicles.

in Minoxidil 43 upvotes 6 years ago

Minoxidil may suppress androgen activity in hair follicles, potentially aiding in hair growth and prostate cancer treatment. Users discuss the effectiveness of minoxidil and finasteride for hair maintenance and regrowth, with some preferring topical applications over oral due to safety concerns.

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