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GlossaryAndrogen Suppression

reducing or blocking male hormones to slow cancer growth

Androgen Suppression, also known as Androgen Deprivation Therapy (ADT), involves reducing or blocking the action of androgens (male hormones like testosterone) to slow the growth of certain cancers, such as prostate cancer. This can be achieved through medications that inhibit androgen production or through surgical procedures like orchiectomy (removal of the testes).

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Research

5 / 1000+ results

research Study Answers Some Questions about Androgen Suppression Pre-Radiation, but Not All

March 2015 in “Oncology Times”

Extending androgen suppression before radiotherapy offers no extra survival benefit for intermediate-risk prostate cancer.

research Suppression of FOXO1 activity by SIRT1-mediated deacetylation weakening the intratumoral androgen autocrine function in glioblastoma

2 citations , March 2025 in “Cancer Gene Therapy”

Targeting Sirt1 can reduce androgen levels and slow glioblastoma growth.

Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part II: Treatment Delivery for Non-Metastatic Biochemical Recurrence After Primary Radical Prostatectomy

research Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part II: Treatment Delivery for Non-metastatic Biochemical Recurrence After Primary Radical Prostatectomy

4 citations , February 2024 in “The Journal of Urology”

Adding hormone therapy to radiation improves survival for high-risk prostate cancer recurrence but has side effects.

5α-Reductase Inhibitors: Finasteride and Dutasteride in Feminizing Therapy

research 5α-reductase Inhibitors: Finasteride and Dutasteride in Feminising Therapy

6 citations , July 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Finasteride and dutasteride have limited use in feminising therapy and are not recommended for routine use.

research Hormonal Therapy for Acne

1 citations , November 1996 in “Journal of Cutaneous Medicine and Surgery”

Hormones, especially androgens, play a key role in causing acne, and treatments like hormone control pills and hormone-blocking medications can help.

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Community Join

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community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 3 years ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community Are these all the anti androgen products?

in Treatment 5 upvotes 2 years ago

The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 2 years ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community I Get Side-Effects from Anti-Androgens

in Finasteride/Dutasteride 8 upvotes 5 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

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