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GlossaryAndrogen Suppression

reducing or blocking male hormones to slow cancer growth

Androgen Suppression, also known as Androgen Deprivation Therapy (ADT), involves reducing or blocking the action of androgens (male hormones like testosterone) to slow the growth of certain cancers, such as prostate cancer. This can be achieved through medications that inhibit androgen production or through surgical procedures like orchiectomy (removal of the testes).

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Research

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research 24-Hydroxycholesterol suppresses steroid 5α-reductase-catalyzed conversion in human glioblastoma cell lines: A novel link between brain cholesterol homeostasis and androgen metabolism

January 2026 in “Neurochemistry International”

24-Hydroxycholesterol reduces DHT formation in brain cancer cells, linking cholesterol and hormone metabolism.

research Low-Dose Dimethyl Sulfoxide (DMSO) Suppresses Androgen Receptor (AR) and Its Splice Variant AR-V7 in Castration-Resistant Prostate Cancer (CRPC) Cells

August 2025 in “Therapeutics”

Low-dose DMSO may help treat castration-resistant prostate cancer by reducing key cancer cell receptors.

research Development of fluridil, a topical suppressor of the androgen receptor in androgenetic alopecia

5 citations , July 2003 in “Drug Development Research”

Fluridil promotes hair growth safely and effectively for androgenetic alopecia.

research Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase

43 citations , August 2016 in “Scientific Reports”

Cinnamomi cortex may help treat prostate enlargement by reducing related proteins.

A New Way to Restore Tumor Suppressor Function

research A new way to restore tumour suppressor function

August 2013 in “Nature Reviews Drug Discovery”

New treatments may restore cancer-blocking proteins, slow prostate cancer, identify drug targets, and potentially regrow hair.

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community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 2 years ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community 2 years of Androgen inhibition.

in Progress Pictures 143 upvotes 10 months ago

A 23-year-old has been using finasteride, dutasteride, and spironolactone to combat hair loss and hormonal acne, with mixed results and concerns about side effects. The user is experimenting with spironolactone despite its potential risks, hoping for skin and body hair improvements.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 3 years ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community Minoxidil is a 5ar inhibitor according to research

in Research/Science 148 upvotes 9 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 2 years ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

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