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research Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt

83 citations , October 2012 in “International Journal of Oncology”

Wedelolactone selectively kills prostate cancer cells without harming normal cells.

research Effects of the androgen receptor overexpression in prostate cancer

January 2007

Androgen receptor overexpression can increase prostate cancer cell growth even without hormones.

research Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity

26 citations , May 2012 in “Cellular and Molecular Life Sciences”

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

research Synthesis of 17β-N-arylcarbamoylandrost-4-en-3-one derivatives and their anti-proliferative effect on human androgen-sensitive LNCaP cell line

11 citations , June 2016 in “European Journal of Medicinal Chemistry”

Compounds 6f and 6g effectively stop prostate cancer cell growth without harming healthy cells.

research Abstract 5561: 20(S)-Protopanaxadiol-aglycone downregulates full-length and ligand-independent splice variants of androgen receptor

April 2011 in “Cancer Research”

20(S)-Protopanaxadiol-aglycone may help prevent and treat prostate cancer by reducing androgen receptor activity.

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community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001).

in Research/Science 294 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%, and type 2 diabetes is linked to female pattern hair loss. Reducing sugar intake and using treatments like finasteride and minoxidil may help manage hair loss.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 3 years ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community Holy shit. Verteporfin may actually be the cure

in Research/Science 1019 upvotes 2 years ago

The post and conversation discuss Verteporfin's potential as a hair loss treatment. It's shown promise in regrowing hair after transplants and might be effective with microneedling.

community Hair loss research is a money grab

in Chat 227 upvotes 8 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community The mechanism of androgenic alopecia

in Research/Science 34 upvotes 10 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

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