PP405 may induce new hair growth but cannot revive completely dead follicles, and its effectiveness on hairlines is uncertain. It is expected to be available by mid-2028, but users are advised to manage expectations and consider using other treatments like minoxidil and finasteride.
GT20029 is a new hairloss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.
User pancake9001 experienced minimal hair growth with Minoxidil for 3 years, but noticed dramatic hairloss after stopping. Replies suggest not stopping Minoxidil and considering adding an anti-androgen for better results.
Akkermansia bacteria can improve hair growth inhibited by testosterone, and metformin may increase Akkermansia, which could help with hairloss related to aging, insulin resistance, and inflammation.
A 25 year old male who has been using finasteride and dutasteride for two years to treat his hairloss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.