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research Study on the mechanism that SNPs related to sex hormone metabolism regulate the imbalance of sex hormones and lead to BPHin rats

July 2026 in “Figshare”

Combining anastrozole with finasteride may better treat hormone imbalance in BPH.

research Study on the mechanism that SNPs related to sex hormone metabolism regulate the imbalance of sex hormones and lead to BPHin rats

July 2026 in “Figshare”

Combining anastrozole with finasteride may better treat hormone imbalance in BPH.

Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat

research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.

22 citations , October 2001 in “Biochemical Pharmacology”

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

research Aspects of Cutaneous Androgen‐Dependent Syndromes

5 citations , September 1980 in “International Journal of Dermatology”

Understanding hormones is key to treating certain skin conditions.

Baldness, Acne, and Testicular Germ Cell Tumors

research Baldness, acne and testicular germ cell tumours

31 citations , December 2010 in “International Journal of Andrology”

Men with testicular cancer were less likely to experience baldness and severe acne.

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community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 4 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community Theoretically won't this be better than finasteride? Azelaic acid + zinc

in Research/Science 7 upvotes 3 years ago

The conversation discusses using zinc sulphate and azelaic acid to inhibit 5 alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.

community Research: Minoxidil grows hair by suppressing androgen activity (DHT) in hair follicles.

in Minoxidil 43 upvotes 6 years ago

Minoxidil may suppress androgen activity in hair follicles, potentially aiding in hair growth and prostate cancer treatment. Users discuss the effectiveness of minoxidil and finasteride for hair maintenance and regrowth, with some preferring topical applications over oral due to safety concerns.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 3 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Minoxidil is NOT an Anti-androgen. No.

in Research/Science 43 upvotes 8 months ago

Minoxidil is not an anti-androgen; it is a growth stimulator and does not lower DHT like finasteride or dutasteride. Minoxidil can cause side effects like facial swelling and anxiety due to its vasodilator properties.

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