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Did you mean Anti-double-stranded DNA antibody?

GlossaryAnti-double-stranded DNA antibody

autoantibodies targeting DNA, linked to autoimmune diseases

Anti-double-stranded DNA (anti-dsDNA) antibodies are autoantibodies that specifically target the double-stranded form of DNA, often associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE). Their relevance to hair loss lies in the fact that autoimmune conditions can lead to hair loss through mechanisms such as inflammation and follicle damage. Key distinguishing characteristics of anti-dsDNA antibodies include their high specificity for SLE and their correlation with disease activity, making them important markers in both diagnosis and monitoring of the disease.

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A Rare Case of Antinuclear Antibody-Negative Systemic Lupus Erythematosus Presenting With Generalized Lymphadenopathy as the Initial Manifestation

research A Rare Case of Antinuclear Antibody-Negative Systemic Lupus Erythematosus Presenting With Generalized Lymphadenopathy as the Initial Manifestation

October 2025 in “Cureus”

A 16-year-old girl with lupus symptoms improved with treatment despite negative ANA tests.

research Abstract 10845: Spontaneous Coronary Artery Dissection as the Primary Presentation of Ana-Negative Lupus

November 2021 in “Circulation”

SCAD can indicate ANA-negative lupus, especially in women with unusual symptoms.

research Life threatening macrophage activation syndrome as the initial presentation of systemic lupus erythematosus: A case report and review of the literature

3 citations , November 2022 in “The Egyptian Rheumatologist”

Macrophage activation syndrome can be a deadly first sign of systemic lupus erythematosus.

research Fever of unknown origin in a male patient with systemic lupus erythematosus.

January 2017 in “PubMed”

SLE should be considered in unexplained fevers, even in males.

research Systemic Lupus Erythematosus: Definitions, Contexts, Conflicts, Enigmas

31 citations , March 2018 in “Frontiers in Immunology”

The document concludes that anti-dsDNA antibodies are not unique to SLE and their use as indicators is doubtful, highlighting the need for better understanding and classification of the disease.

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