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Antisense Oligonucleotide Targeting Fibroblast Growth Factor Receptor-1 Stimulates Cellular Activity of Hair Follicles in an In Vitro Organ Culture System

research Antisense oligonucleotide targeting fibroblast growth factor receptor (FGFR)-1 stimulates cellular activity of hair follicles in anin vitroorgan culture system

7 citations , March 2007 in “International Journal of Dermatology”

Targeting FGFR-1 with antisense oligonucleotides may help treat baldness by increasing hair follicle activity.

research Control of androgen receptor expression in human keratinocytes and in a reconstituted human epidermis model with selective antisense oligonucleotides

1 citations , January 2005 in “Experimental Dermatology”

Antisense oligonucleotides can reduce androgen receptor levels in skin cells, suggesting potential for treating skin disorders.

research Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides

April 2025 in “BMC Immunology”

Targeting SIRT1 with antisense oligonucleotides could be a promising treatment for hair loss.

research Spherical Nucleic Acids as Emerging Topical Therapeutics: A Focus on Psoriasis

6 citations , January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

New topical treatment using spherical nucleic acids shows promise in reducing psoriasis inflammation.

research 487 Exploring ribosomal RNA modifications and corresponding snoRNAs in human skin cell senescence

November 2024 in “Journal of Investigative Dermatology”

Understanding snoRNA regulation may help slow skin aging.

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community Sugar and Hair loss connections

in Research/Science 41 upvotes 1 year ago

High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

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