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Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease

25 citations , June 2019 in “Endocrine Related Cancer”

Mutations in certain receptors can cause diseases and offer new treatment options.

research Androgen receptor modulators: a review of recent patents and reports (2012-2018)

23 citations , May 2019 in “Expert Opinion on Therapeutic Patents”

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

research Structural perspectives on the androgen receptor, the elusive shape-shifter

August 2024 in “Steroids”

The androgen receptor's shape-changing ability helps it function but can lead to cancer treatment resistance.

research The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific

12 citations , June 2013 in “The Prostate”

Dutasteride and finasteride affect different cell types differently.

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community The closest thing to a cure before hair cloning or genetic via?

in Treatment 9 upvotes 3 years ago

The conversation discusses using finasteride or dutasteride to reduce DHT, CosmeRNA to target androgen receptors, and Minoxidil as a vasodilator for hair growth. The regimen aims to maintain hair by addressing DHT-AR ratio and continuous Minoxidil use.

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