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research Androgen binding profiles of two distinct nuclear androgen receptors in Atlantic croaker (Micropogonias undulatus)
Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.
research The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model
Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.
research Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients
The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.
research Androgen receptor modulators: a review of recent patents and reports (2012-2018)
New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.
research Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells
PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.
Community Join
5 / 1000+ resultscommunity Hair loss causes are still a myth.
The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.
community Is it possible for Dutasteride to make one mentally slow?
Dutasteride may cause mental fog, vision blurriness, and sleep issues. Users suggest trying topical versions of the drug to mitigate side effects.
community 8 years of Finasteride and Minoxidil (includes a photo)
User has used Finasteride, Minoxidil, and derma roller for 8 years to treat hair loss but is still losing the battle. Others suggest trying Dutasteride, oral Minoxidil, RU58841, or considering a hair transplant.
community Explanation for "dutasteride destroyed my hair"
Dutasteride can drastically reduce sebum production, leading to dryer hair and shedding. Alternating shampoos and periodic silica supplementation can improve hair quality and thickness.
community AH-001 another topical AR degrader beside GT20029, completed Phase I
AH-001 is a new topical treatment designed to degrade androgen receptors, targeting the root cause of androgenetic alopecia without the side effects of oral treatments like finasteride. It has shown a strong safety profile and good local tolerability in early trials.