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GlossaryArachidonic Acid

polyunsaturated omega-6 fatty acid involved in inflammation and signaling

Arachidonic Acid (AA) is a polyunsaturated omega-6 fatty acid that is a key component of cell membranes. It plays a crucial role in the body's inflammatory response and is a precursor to various signaling molecules called eicosanoids, which include prostaglandins, thromboxanes, and leukotrienes. These molecules are involved in processes such as inflammation, immunity, and the regulation of blood pressure.

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research Role of Arachidonic Acid in Promoting Hair Growth

29 citations , January 2016 in “Annals of dermatology/Annals of Dermatology”

Arachidonic acid helps hair grow by increasing growth factors and improving follicle health.

research Effect of VEGF and minoxidil on the production of arachidonic acid metabolites by cultured hair, dermal papilla cells

1 citations , January 1996 in “European Journal of Dermatology”

VEGF and minoxidil affect hair growth by altering eicosanoid production in hair cells.

research Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin

January 2025 in “Cellular & Molecular Biology Letters”

Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.

Loss of Adipocyte Phospholipase Gene PLAAT3 Causes Lipodystrophy and Insulin Resistance Due to Inactivated Arachidonic Acid-Mediated PPARγ Signaling

research Loss of adipocyte phospholipase gene PLAAT3 causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPARγ signaling

April 2021

Not having the gene PLAAT3 leads to fat loss, high insulin resistance, and abnormal fat levels in the blood due to a disruption in fat cell development and function.

Abnormal Essential Fatty Acid Composition of Tissue Lipids in Genetically Diabetic Mice Is Partially Corrected by Dietary Linoleic and Gamma-Linolenic Acids

research Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic and γ-linolenic acids

20 citations , May 1985 in “British journal of nutrition”

Dietary essential fatty acids improved skin and hair conditions and partially corrected fat composition in diabetic mice.

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community Painkillers May Block Minoxidil

in Research/Science 14 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

in Research/Science 3 upvotes 1 year ago

DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

community Why is there no feedback on pge2/setipiprant?

in Question 5 upvotes 9 years ago

The conversation questions the lack of feedback on the effectiveness of PGE2 and setipiprant for hair loss, despite their availability. The user is puzzled by the absence of reviews or results, whether positive or negative.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 444 upvotes 5 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

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