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research Cross-species comparative spatial transcriptomics of hair follicle-T cell interactions identifies conserved drivers of cutaneous lupus erythematosus skin disease and associated hair loss

July 2026 in “Nature Communications”

CXCR3+ T cells and B cells drive skin disease and hair loss in lupus, with potential targets identified for treatment.

research Vitamin D receptor depletion by Wnt/beta-catenin signaling caused alopecia areata in human Immunobiology, Alopecia Areata

January 2010 in “Seoul National University Open Repository (Seoul National University)”

Lack of Vitamin D receptors can cause hair loss.

research Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells

1 citations , May 2026 in “Nature Communications”

CD19-CAR T cell therapy may help regenerate skin in systemic sclerosis.

research A rare case of TEN-like acute cutaneous lupus

1 citations , April 2024 in “Clinical Medicine”

Timely diagnosis and aggressive treatment with high-dose steroids and B-cell depletion therapies are effective for severe acute cutaneous lupus.

research The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development

16 citations , March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.

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community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 209 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Feeling energyless and think my 2.5mg dut per day might be causing it

in Research/Science 20 upvotes 1 year ago

Taking 2.5mg of dutasteride daily can cause feelings of low energy, ambition, and motivation, likely due to hormonal imbalances. Many users suggest lowering the dose to 0.5mg to alleviate these side effects.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 47 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 484 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

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learn Beta Polypeptide

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