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GlossaryBasal Cell Carcinoma

most common skin cancer, originating in basal epidermal cells

Basal Cell Carcinoma (BCC) is the most common type of skin cancer, originating in the basal cells, which are found in the deepest layer of the epidermis. It typically appears as a small, shiny bump or nodule on sun-exposed areas of the skin, such as the face and neck, and is usually caused by long-term exposure to ultraviolet (UV) radiation from the sun or tanning beds. While BCC rarely metastasizes, it can cause significant local damage if not treated promptly.

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research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

380 citations , March 2000 in “Proceedings of the National Academy of Sciences”

Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.

research Identification of the cell lineage at the origin of basal cell carcinoma

351 citations , February 2010 in “Nature Cell Biology”

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

333 citations , March 2000 in “Proceedings of the National Academy of Sciences”

Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.

research Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

178 citations , April 2011 in “Journal of Clinical Investigation”

Basal cell carcinomas in mice can start from hair follicle stem cells and other skin cell types, depending on signaling levels.

research Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells

133 citations , March 1999 in “Journal of Cutaneous Pathology”

Trichoepitheliomas and some basal cell carcinomas likely come from hair follicle stem cells.

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