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      Whole Tooth Regenerative Therapy Using a Bioengineered Tooth Germ

      research Whole Tooth Regenerative Therapy Using a Bioengineered Tooth Germ

      2 citations , December 2013 in “Current Oral Health Reports”
      The document discussed the development of whole tooth regenerative therapy using bioengineered tooth germs as a novel approach to address dental disorders. This therapy aimed to replace lost or damaged teeth with bioengineered teeth that could fully restore oral functions. The research highlighted the potential of using stem cells, particularly dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHED), to regenerate tooth structures. Various methods, including biodegradable scaffolds and cell aggregation techniques, were explored to create bioengineered tooth germs capable of developing into functional teeth. The ultimate goal was to achieve a fully functional bioengineered tooth unit that could integrate with the recipient's jawbone, providing a biological alternative to artificial dental replacements. The study demonstrated the potential for successful transplantation, eruption, and occlusion in animal models, maintaining functional periodontal ligaments and proper bone integration. However, challenges remained in identifying suitable cell sources and controlling tooth morphology for clinical applications.

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