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research 42134 Long-term Efficacy of Guselkumab (GUS) on Fatigue and Identification of Early Treatment Targets: Post Hoc Analysis Through 2 Years of a Phase 3, Randomized, Double-blind, Placebo-controlled Study in Biologic-naïve Patients With Psoriatic Arthritis (PsA)

September 2023 in “Journal of the American Academy of Dermatology”

Guselkumab effectively reduces fatigue in Psoriatic Arthritis patients over two years.

research Human long-term deregulated circadian rhythm alters regenerative properties of skin and hair precursor cells

9 citations , July 2018 in “European journal of dermatology/EJD. European journal of dermatology”

Disrupted sleep patterns can harm skin and hair cell renewal, but melatonin might help.

research Treatments for alopecia areata: a network meta-analysis

1 citations , September 2020 in “Cochrane library (CD-ROM)”

The analysis aims to identify the most effective and safest treatments for alopecia areata.

research Poly (lactic-co-glycolic acid)-based microneedles for drug delivery across different biological barriers

December 2025 in “International Journal of Pharmaceutics”

PLGA-based microneedles show promise for painless, long-term drug delivery but need design and safety improvements.

research Differences in Self-Reported Stress Versus. Hair and Nail Cortisol Among Adolescent and Young Adult Males

July 2024 in “Nursing Research”

Hair and nail cortisol levels can show long-term stress in young males.

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Community Join

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community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

in Research/Science 5 upvotes 3 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

community Will my liver get destroyed long term on this stack ??

in Chat 15 upvotes 2 years ago

A user is considering a long-term hair loss treatment stack including Dutasteride, Finasteride, and oral Minoxidil, and is concerned about potential liver damage. Some responses suggest the stack is excessive, while others believe it's not harmful to the liver, but recommend regular blood work to monitor health.

community 42 male - 8 months (Is this the biological limit?)

in Progress Pictures 61 upvotes 3 months ago

A 42-year-old male has reached a plateau in hair regrowth after 8 months using Dutasteride, Minoxidil, a dermaroller, and Ketoconazole. Suggestions include continuing treatment, considering a hair transplant, and improving nutrition.

community Why hasn’t anyone made a "DHT sponge" biologic yet???

in Research/Science 45 upvotes 8 months ago

The conversation discusses the potential for developing a biologic "DHT sponge" to neutralize DHT in the bloodstream as a treatment for hair loss, suggesting it could be more targeted and have fewer side effects than current treatments like finasteride and dutasteride. Concerns include the complexity, cost, and potential side effects of such a treatment, as well as skepticism about its feasibility and market interest.

community Has anyone here been on finasteride for longer than 10 years? If so, have you had any major issues with the medicine please share your experience and how long you have taken the medicine.

in Treatment 112 upvotes 7 months ago

Long-term finasteride use typically slows hair loss, with some users experiencing side effects like sexual dysfunction and depression. Many users also use minoxidil and dutasteride for improved results, though individual responses vary.

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Learn

5 / 801 results

learn Thymosin Beta 4

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

learn Beta Polypeptide

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Clinics

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24
Trichology
Real Trans Hair Biological Rejuvenation ClinicMoscow · RU

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