6 citations
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January 2022 in “Journal of Investigative Dermatology”
Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of bloodvessels and hair loss. Early treatment targeting this receptor could be more effective.
The post discusses a theory that hair regrowth after transplant is due to the angiogenesis process (new bloodvessels forming), not because the transplanted hair is unaffected by DHT. The responses highlight the established belief in 'donor dominance' (the importance of the hair's origin in transplantation) and skepticism about the new theory.
Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes bloodvessel loss and hair follicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hair loss.
The conversation is about someone experiencing a lot of bleeding from using a 1.0mm microneedling device for hair loss treatment and asking if it's normal. Various users suggest that the bleeding is excessive and recommend using shorter needles or less pressure, while others share their own microneedling practices with different needle lengths and no bleeding.
The user started using finasteride, minoxidil, and biotin for male pattern baldness (MPB) and is experiencing rapid thinning. They are questioning if low blood flow to the head could be contributing to their hair loss.
Minoxidil helps hair growth by increasing blood flow and prolonging the growth phase, but it doesn't address the root cause of hair loss, such as DHT sensitivity. Finasteride can help maintain some gains by blocking DHT, but stopping Minoxidil often leads to hair loss because the new hairs are dependent on it.