Search
forLearn
5 / 801 resultslearn KB solution
learn PTD-DBM
learn HT-B
learn K&B
Research
5 / 1000+ results
research FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery
The study introduces a finite element analysis (FEA)-guided co-design framework for developing separable bubble microneedles (BMNs) that optimize geometry and cavity parameters for controlled tip separation and robust insertion. The research demonstrated that minoxidil sulfate-loaded BMNs (MXS-BMNs) and insulin-loaded BMNs (INS-BMNs) achieved effective transdermal and sublingual delivery, respectively. MXS-BMNs showed a sevenfold increase in minoxidil permeation compared to topical gel and accelerated hair regrowth in mice, while INS-BMNs provided rapid glucose reduction in diabetic rats. The FEA predictions closely matched experimental results, confirming the framework's efficacy in reducing empirical iteration and expediting BMN development for rapid drug delivery.
research FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery
The study introduces a finite element analysis (FEA)-guided co-design framework for developing separable bubble microneedles (BMNs) that optimize geometry and cavity parameters for controlled tip separation and robust insertion. The research demonstrated that minoxidil sulfate-loaded BMNs (MXS-BMNs) and insulin-loaded BMNs (INS-BMNs) achieved effective transdermal and sublingual delivery, respectively, with separation forces closely matching FEA predictions and axial strengths surpassing skin and mucosa penetration thresholds. In vivo tests showed MXS-BMNs significantly enhanced hair regrowth in mice, while INS-BMNs effectively lowered glucose levels in diabetic rats. This approach reduces empirical iteration, facilitating the rapid development of efficient microneedle systems for drug delivery.
research Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment
New microneedle treatment with growth factors and a hair loss drug shows better and faster hair growth results than current treatments.
research Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment
Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.
research Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics
Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.
Community Join
5 / 1000+ resultscommunity Possible topical option for preventing BDNF-related hair loss
The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.
community PTD-DBM Update: Q&A With Dr. Kang-Yell Choi
PTD-DBM is being explored for hair regrowth by targeting CXXC5, with clinical trials expected after pre-clinical studies. Users express anticipation and skepticism about its effectiveness.
community Counter-update: Cbum's transplant DOESNT look super good now
Cbum's hair transplant is criticized for looking unnatural and not blending well, with some suggesting better results were expected given his resources. Discussions also cover the effects of steroids and finasteride on hair loss and muscle growth.
community How much do we know about PTD-DBM?
PTD-DBM is a Korean-developed treatment for hair loss, with limited information available and some users testing it personally. A user purchased PTD-DBM for $115 and plans to test it on their temples, but its effectiveness and authenticity remain uncertain.
community Oral PTD-DBM available online, worth giving a shot?
Oral PTD-DBM was discussed as a potential hair loss treatment, but it was deemed ineffective in humans despite promising results in mice. The conversation concluded that trying it without VPA might be unwise.