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5 / 1000+ resultsresearch The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis
The study explores the use of the melanocortin compound BMS-470539 to target fibrosis by inducing a 'senescence-like' state in human dermal fibroblasts, particularly from systemic sclerosis patients. This state is characterized by proliferation arrest and reduced pro-inflammatory activity, leading to the downregulation of fibrosis markers. In vitro and in vivo models, including a bleomycin-induced skin fibrosis murine model, demonstrated that BMS-470539 effectively reduced skin thickness and fibrosis markers without causing additional fibrosis when administered intradermally. The findings suggest a promising therapeutic strategy to manage fibrosis and potentially other diseases with shared pathogenic mechanisms, such as arthritis.
research Can we teach old drugs new tricks?—Repurposing of neuropharmacological drugs for inflammatory skin diseases
Old neuropharmacological drugs might be effective for treating inflammatory skin diseases.
research Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
The skin's basement membrane has specialized structures and molecules for different tissue interactions, important for hair growth and attachment.
research Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
The skin's basement membrane is specially designed to support different types of connections between skin layers and hair follicles.
research A Window into Mammalian Basement Membrane Development: Insights from themTurq2-Col4a1Mouse Model
The mTurq2-Col4a1 mouse model shows that cells can divide while attached to stable basement membranes during development.
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5 / 1000+ resultscommunity Huge Group Buy is Now Live with New and Existing Treatments
A group buy for hair loss treatments including Harmine 19a, TM5614, Abiraterone Acetate, and others. A compound, BMS-202, that can potentially reverse gray hair is also mentioned.
community I was scared of Fin. I now love it
A 25-year-old male switched from multiple topicals to finasteride and minoxidil for hair loss, experiencing maintenance and increased confidence despite minor side effects. He now styles his hair freely and appreciates the positive impact of finasteride.
community New Treatments, and a Huge Group Buy with Lots of Research
A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.
community CB-03-01 / Breezula Personal Results
The user shared their experience with CB-03-01 (Breezula/Clascoterone) for hair loss, noting reduced shedding and improved hair appearance but experiencing significant sleep disturbances and low energy due to HPA axis suppression. They decided to stop using it due to these side effects and are waiting for GT20029 as an alternative.
community bpc-157 scalp injections. 3 months
The user experienced reduced hair shedding after three months of injecting 1mg BPC-157 into the scalp, while continuing to use dutasteride and minoxidil. The injections are painful, and the user sometimes switches to injecting into the buttocks.