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Inhibition of Autophagy-Lysosomal Function Exacerbates Microglial and Monocyte Lipid Metabolism Reprogramming and Dysfunction After Brain Injury

research Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury

September 2025

Blocking autophagy worsens lipid buildup and dysfunction in brain cells after injury.

research SHORT-TERM DIABETES IN THE BRAIN: EFFECTS ON NEUROACTIVE STEROIDS, CHOLESTEROL HOMEOSTASIS, AND MITOCHONDRIAL FUNCTIONALITY

January 2017 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)”

Short-term diabetes can cause changes in brain steroids, cholesterol balance, and mitochondrial function.

research Comparison of brain functional response to mechanical prickling stimuli to the glabrous and hairy skin

5 citations , August 2023 in “Skin Research and Technology”

Hairy skin feels prickling more intensely than smooth skin.

research On the effects of testosterone on brain behavioral functions

186 citations , February 2015 in “Frontiers in Neuroscience”

Testosterone affects brain behavior in complex and varied ways.

research Group-ICA Model Order Highlights Patterns of Functional Brain Connectivity

109 citations , January 2011 in “Frontiers in Systems Neuroscience”

Choosing the right model order in brain connectivity analysis can affect the detection of differences between healthy individuals and those with seasonal affective disorder.

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community Fin and Brain Fog

5 upvotes 10 years ago

The conversation discusses concerns about brain fog potentially caused by finasteride use, with some users sharing personal experiences of cognitive issues and others suggesting it might be paranoia or unrelated. The original poster decides to stop using finasteride to see if their cognitive function improves.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 2 years ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community It is what it is with some people

in Satire 162 upvotes 7 months ago

Hair loss treatments like finasteride and dutasteride are discussed, with concerns about side effects such as depression and brain fog. Some users argue about the necessity and impact of DHT on libido and other bodily functions.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

in Finasteride/Dutasteride 290 upvotes 1 year ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

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