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research A Phase 2a Study Investigating the Effects of Ritlecitinib on Brainstem Auditory Evoked Potentials and Intraepidermal Nerve Fiber Histology in Adults with Alopecia Areata

4 citations , July 2024 in “Pharmacology Research & Perspectives”

This phase 2a, double-blind study evaluated the effects of ritlecitinib on brainstem auditory evoked potentials (BAEP) and intraepidermal nerve fiber (IENF) histology in 71 adults with alopecia areata. Participants received either ritlecitinib or a placebo for 9 months. The study found no significant differences in BAEP changes or IENF histology between the ritlecitinib and placebo groups. Additionally, there was no increased incidence of neurological or audiological adverse events associated with ritlecitinib. These findings suggest that the axonal swelling and BAEP changes observed in dogs are not clinically relevant in humans.

research Two-Year Follow-Up of Two Patients After Severe Thallium Intoxication

52 citations , May 2009 in “Human & experimental toxicology”

Hair loss and polyneuropathy improved, but severe vision impairment persisted.

research Diagnosed With Primary Adrenal Insufficiency? Search Adrenoleukodystrophy - Two Brothers Presented With Similar Phenotype

June 2023 in “International Journal of Research in Medical Sciences”

Two brothers from Bangladesh were diagnosed with X-linked adrenoleukodystrophy, showing neurological and adrenal symptoms.

research A Japanese Case of Ichthyosis Follicularis with Atrichia and Photophobia Syndrome with an MBTPS2 Mutation

14 citations , December 2010 in “Journal of human genetics”

A Japanese patient with IFAP syndrome had a severe MBTPS2 gene mutation but showed milder symptoms than previously observed cases.

research Cytostatics and Immunosuppressive Drugs: Toxicities and Management

January 1989 in “Side effects of drugs annual”

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

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community Microneedling must reach the stem cells in the upper hair shaft

in Treatment 82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community Anyone remember Breezula, the promising hairloss drug that was perpetually 3 years away? Well, it's available right now as an acme treatment. Can we just directly apply to the scalp?

in Treatment 43 upvotes 4 years ago

The conversation discusses the availability of Breezula, a drug for hair loss, now being sold as an acne treatment, and whether it can be applied to the scalp. Users express skepticism about new hair loss treatments and suggest waiting for FDA approval.

community Hey /r/ Tressless, thought it would be interesting to take a full journey of hair restoration with you! DAY 1825

in Finasteride/Dutasteride 17 upvotes 5 years ago

The efficacy of various hair loss treatments, including Finasteride and Dutasteride, with personal anecdotal evidence about potential side effects. It also includes advice to get a male hormone blood panel done before starting treatment, and lifestyle changes to minimize side effects.

community Can’t tolerate oral fin at any dosage, help me brainstorm a treatment plan.

in Treatment 9 upvotes 1 year ago

The user cannot tolerate oral finasteride and is considering topical finasteride, minoxidil, microneedling, and RU58841 as alternative treatments for hair loss. They seek advice on whether these options are worth trying.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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