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GlossaryBRCA1

gene involved in DNA repair, linked to cancer risk

BRCA1 is a gene that produces a protein responsible for repairing damaged DNA, playing a crucial role in maintaining the genetic stability of cells. Mutations in the BRCA1 gene can lead to a significantly increased risk of developing breast and ovarian cancers, as the defective protein fails to properly repair DNA, allowing genetic mutations to accumulate.

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BRCA2 in Abscission: Role in Cytokinesis and Recruitment of Abscission Regulators

research BRCA2 in abscission

August 2012 in “Nature Cell Biology”

The tumor suppressor BRCA2 helps in cell division by bringing key proteins to the area where cells split.

research Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1

48 citations , October 2004 in “Molecular and Cellular Biology”

Mice with a specific BRCA1 mutation have a higher risk of tumors, especially in the uterus and ovaries.

research Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas

January 2019 in “Dermatologic Surgery”

Hormone Replacement Therapy for Women with Premature Ovarian Insufficiency: A Comprehensive Review

research HRT for women with premature ovarian insufficiency: a comprehensive review

61 citations , January 2017 in “Human Reproduction Open”

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

research One of These Things Is Not Like the Others: The Idea of Precedence in Health Technology Assessment and Coverage Decisions

35 citations , June 2005 in “The Milbank Quarterly”

The conclusion is that formalizing how past decisions influence current health technology assessments could improve the credibility and defense of coverage decisions.

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