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      research Biotinidase Deficiency: Prevalence, Impact And Management Strategies.

      89 citations , January 2020 in “PubMed”
      Biotinidase deficiency (BTD) was a metabolic disorder that, if untreated, could lead to severe neurological and dermatological symptoms such as seizures, developmental delays, alopecia, and skin rashes. The disorder was caused by genetic mutations in the BTD gene, with over 200 mutations identified. The severity of symptoms depended on the level of enzyme activity, with profound deficiency classified as less than 10% of normal serum activity. Early detection through newborn screening and treatment with oral biotin significantly improved outcomes, preventing severe manifestations and increasing asymptomatic cases. However, some symptoms, like auditory and visual defects, could persist despite treatment. Newborn screening programs, initiated in 1984, were crucial for early detection and management, although long-term natural history data was limited.

      research Biotin and biotinidase deficiency

      166 citations , November 2008 in “Expert Review of Endocrinology & Metabolism”
      Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.

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      community How much do we know about PTD-DBM?

      in Question  7 upvotes 7 years ago
      PTD-DBM is a Korean-developed treatment for hair loss, with limited information available and some users testing it personally. A user purchased PTD-DBM for $115 and plans to test it on their temples, but its effectiveness and authenticity remain uncertain.

      community ET-02 Now Recruiting in Texas for Phase 1

      in Research/Science  20 upvotes 1 year ago
      Eirion Therapeutics is recruiting for phase 1 of ET-02 in Texas, which showed promising hair growth results in non-clinical studies. ET-02 demonstrated significantly more hair growth compared to Minoxidil.

      community PTD-DBM Update: Q&A With Dr. Kang-Yell Choi

      in Treatment  14 upvotes 6 years ago
      PTD-DBM is being explored for hair regrowth by targeting CXXC5, with clinical trials expected after pre-clinical studies. Users express anticipation and skepticism about its effectiveness.