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GlossaryBusulfan

chemotherapy drug used to treat certain cancers

Busulfan is a chemotherapy drug primarily used to treat certain types of cancer, such as chronic myelogenous leukemia (CML). It works by interfering with the DNA inside cancer cells, preventing them from growing and dividing. However, it can also cause side effects like hair loss (alopecia) and damage to bone marrow, which is why its use is carefully monitored by healthcare professionals.

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Research

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research Six cases of permanent alopecia after various conditioning regimens commonly used in hematopoietic stem cell transplantation

40 citations , September 2007 in “Bone marrow transplantation”

Certain chemotherapy drugs can cause permanent hair loss in stem cell transplant patients.

research Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

32 citations , August 2019 in “Nature Communications”

Chemotherapy causes permanent hair follicle damage by triggering stem cell loss.

research Clinical and histological study of permanent alopecia after bone marrow transplantation

23 citations , December 2015 in “Anais Brasileiros de Dermatologia”

Permanent hair loss after bone marrow transplant can be caused by chemotherapy or chronic graft-versus-host disease.

Permanent Diffuse Alopecia After Hematopoietic Stem Cell Transplantation in Childhood

research Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood

16 citations , March 2017 in “Bone Marrow Transplantation”

Some children who had stem cell transplants developed permanent hair loss, especially when treated with a drug called busulphan.

research Radiation- and Chemotherapy-Induced Permanent Alopecia: Case Series

14 citations , January 2013 in “Journal of Cutaneous Medicine and Surgery”

Some cancer treatments can cause permanent hair loss.

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Community Join

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community Pirfenidone - The answer to fibrosis and baldness

in Treatment 17 upvotes 4 years ago

Pirfenidone is suggested to treat fibrosis and baldness by blocking inflammation markers and reducing collagen. It is also available as a gel for scar removal.

community Pyrilutamide available at Actifolic now

in Research/Science 15 upvotes 3 years ago

Pyrilutamide, a new hair loss product with the potential to be more effective than RU58841 and safer than CB, but expensive.

community Breezula hasn't even begun phase 3 trials yet. F*cking hell.

in Treatment 44 upvotes 4 years ago

The conversation is about the delay in Breezula's phase 3 trials and skepticism regarding its effectiveness compared to other treatments like RU58841 and Pyrilutamide. Some users prefer safety over effectiveness, while others express frustration with the slow progress and doubt Breezula will be a significant treatment for hair loss.

community What happened to Breezula ????

in Research/Science 11 upvotes 3 years ago

The conversation discusses the effectiveness of a hair loss treatment called CB (Breezula) in comparison to Pyrilutamide, and its potential when combined with Finasteride. There is uncertainty about when or if phase 3 trials for Breezula will begin.

community July 1st - Early H2 - Breezula

in Treatment 1 upvotes 9 months ago

Discussion on hair loss treatments, focusing on Breezula, with mentions of Minoxidil, finasteride, RU58841, Pyrilutamide, GT20029, and PP405. Breezula's effectiveness is uncertain, with some trials showing minimal regrowth.

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