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GlossaryBusulfan

chemotherapy drug used to treat certain cancers

Busulfan is a chemotherapy drug primarily used to treat certain types of cancer, such as chronic myelogenous leukemia (CML). It works by interfering with the DNA inside cancer cells, preventing them from growing and dividing. However, it can also cause side effects like hair loss (alopecia) and damage to bone marrow, which is why its use is carefully monitored by healthcare professionals.

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Priming Mobilization of Hair Follicle Stem Cells Triggers Permanent Loss of Regeneration After Alkylating Chemotherapy

research Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

32 citations , August 2019 in “Nature Communications”

Chemotherapy causes permanent hair follicle damage by triggering stem cell loss.

Clinical and Histological Study of Permanent Alopecia After Bone Marrow Transplantation

research Clinical and histological study of permanent alopecia after bone marrow transplantation

23 citations , December 2015 in “Anais Brasileiros de Dermatologia”

Permanent hair loss after bone marrow transplant can be caused by chemotherapy or chronic graft-versus-host disease.

Permanent Diffuse Alopecia After Hematopoietic Stem Cell Transplantation in Childhood

research Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood

16 citations , March 2017 in “Bone Marrow Transplantation”

Some children who had stem cell transplants developed permanent hair loss, especially when treated with a drug called busulphan.

Radiation- and Chemotherapy-Induced Permanent Alopecia: Case Series

research Radiation- and Chemotherapy-Induced Permanent Alopecia: Case Series

14 citations , January 2013 in “Journal of Cutaneous Medicine and Surgery”

Some cancer treatments can cause permanent hair loss.

Non-Malignant Late Cutaneous Changes After Allogeneic Hematopoietic Stem Cell Transplant in Children

research Nonmalignant late cutaneous changes after allogeneic hematopoietic stem cell transplant in children

7 citations , March 2018 in “Journal of The American Academy of Dermatology”

Skin changes like hair loss, white patches, and nail changes are common in children after bone marrow transplants, often linked to chronic rejection.

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