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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research 576 A preliminary study of melanogenic markers in the differentiation of the human hair follicle melanin unit

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study found markers indicating that cells responsible for hair color are differentiating in specific areas of the hair follicle.

research Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis

29 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.

research Author reply

1 citations , April 2004 in “Cancer”

Imatinib mesylate can cause skin lightening, especially in Chinese patients, due to its effect on pigment production.

research The Immunohistochemical Changes of Skin during Hair Follicle Cycle after Depilation in Mice

7 citations , December 2010 in “대한의생명과학회지”

Hair growth after depilation increases skin thickness, mast cell counts, and cell activity.

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community The Golden Hair Regrowth/Loss Prevention Regimen With Results and Explanation

in Treatment 224 upvotes 4 years ago

Hair loss prevention and regrowth regimen includes finasteride, oral minoxidil, stemoxydine, hair growth serum, derma rolling, and ketocanazole shampoo. Users discuss efficacy, safety, and personal experiences with treatments.

community C’est terrible - at my wits end

in Female 450 upvotes 2 years ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

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Hair Transplant Surgeon
Dr. Kitti Kovacs, MD
Budapest, Hungary
6+ yrs

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Dr. Kitti Kovacs, MD