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Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

57 citations , April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

research Genetic variants in AR and SHBG and resistance to hormonal castration in prostate cancer

6 citations , February 2013 in “Medical Oncology”

Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.

research Low-Dose Dimethyl Sulfoxide (DMSO) Suppresses Androgen Receptor (AR) and Its Splice Variant AR-V7 in Castration-Resistant Prostate Cancer (CRPC) Cells

August 2025 in “Therapeutics”

Low-dose DMSO may help treat castration-resistant prostate cancer by reducing key cancer cell receptors.

research Insight into Recent Advances in Degrading Androgen Receptor for Castration-Resistant Prostate Cancer

February 2024 in “Cancers”

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

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community Dude had better hair at over 100 years of age than many of us at 20

in Satire 1452 upvotes 3 years ago

Hair loss discussion mentions Native Americans' resistance to male pattern baldness and lack of facial hair. Users discuss genetics, sun exposure, and potential treatments like minoxidil and finasteride.

community What would an actual nuclear stack look like?

in Chat 41 upvotes 2 months ago

The conversation discusses various treatments for hair loss, including high doses of dutasteride, oral minoxidil, RU58841, microneedling, ketoconazole shampoo, and other supplements like pumpkin seed oil and multivitamins. It also touches on more extreme measures like estrogen therapy and castration, with some users emphasizing the importance of overall health and nutrition.

community Twist1 Group Buy: Yes it’s that easy

in Research/Science 39 upvotes 3 years ago

A group buy for testing a compound targeting Twist1 protein as a potential hair loss treatment. Inhibiting Twist1, which keeps hair follicles in growth phase, may prevent hair loss with minimal side effects.

community Some among us are the chosen ones

in Chat 122 upvotes 1 year ago

Some individuals experience hair loss despite using treatments like 2.5 mg dutasteride, finasteride, and minoxidil, suggesting sensitivity to DHT or other factors. Various treatments and lifestyle changes are discussed, but results vary, and some consider hair transplants or other solutions.

community Went home for the holidays and my Dad asked ‘what have you done to your hair?’ he was genuinely happy for me and supportive when I told him I was growing it back with finasteride. AMA – 7 months in.

in Progress Pictures 534 upvotes 4 years ago

User experienced significant hair regrowth after 7 months of using 0.5mg finasteride, along with minoxidil and dermastamp. Side effects include increased sensitivity to poor lifestyle choices, but overall confidence improved.

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