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Glossaryp21 (CDK inhibitor 1)

protein that inhibits cell cycle progression for DNA repair

p21 is a protein that acts as a regulator of the cell cycle. It is known for its role in inhibiting the activity of cyclin-dependent kinases (CDKs), which are crucial for cell division. By doing so, p21 can halt the cell cycle, allowing for DNA repair or triggering cell death if the damage is irreparable. This function is particularly important in preventing the proliferation of damaged cells, which can lead to cancer.

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research Establishment and Characterization of Immortalized Human Dermal Papilla Cells Expressing Human Papillomavirus 16 E6/E7

1 citations , November 2023 in “Journal of Microbiology and Biotechnology”

The study successfully established immortalized human dermal papilla cells (HDPCs) by transfecting them with human papillomavirus 16 (HPV16) E6/E7 oncogenes, overcoming the limitations of primary HDPCs such as reduced proliferative capacity and hair induction potential. These immortalized cells demonstrated higher proliferative activity, with downregulated p53 and pRb proteins and decreased expression of the CDK inhibitor p21. Additionally, cell cycle-related genes and proteins, including CDK2, cyclin E, and E2F family genes, were upregulated. Importantly, the immortalized HDPCs retained their ability to respond to the Wnt/β-catenin pathway and form hair follicles, making them valuable for in vitro hair growth and regeneration studies.

research Activation of the Integrated Stress Response in Human Hair Follicles

June 2024 in “PLoS ONE”

Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.

research Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues

111 citations , June 2002 in “The EMBO Journal”

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research Androgen Receptor: A Promising Therapeutic Target in Breast Cancer

21 citations , March 2019 in “Critical Reviews in Clinical Laboratory Sciences”

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

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