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Did you mean Cell cycle inhibitor?

GlossaryCell cycle inhibitor

molecule that halts or slows down cell division

A cell cycle inhibitor, also known as a cell cycle suppressor or cell cycle regulator, is a molecule that can halt or slow down the process of cell division. These inhibitors play a crucial role in controlling cell growth and ensuring that cells do not divide uncontrollably, which is important for preventing conditions like cancer. For example, proteins like p21 and p27 are well-known cell cycle inhibitors that can stop the cell cycle at specific checkpoints, allowing for DNA repair or triggering cell death if the damage is irreparable.

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Research

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Maternal Androgen Excess Inhibits Fetal Cardiomyocyte Proliferation Through RB-Mediated Cell Cycle Arrest and Induces Cardiac Hypertrophy in Adulthood

research Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood

2 citations , August 2023 in “Journal of Endocrinological Investigation”

Excess maternal androgens can cause heart problems in offspring.

research Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice

February 2024 in “Journal of Investigative Dermatology”

Deleting NIPP1 in mouse skin cells causes early aging and chronic skin issues.

Temporary Cell Cycle Arrest by ALRN-6924: A Novel P53-Targeting Strategy to Protect Human Scalp Hair Follicles Against Cyclophosphamide-Induced Alopecia

research 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia

April 2023 in “Journal of Investigative Dermatology”

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

research Immune cell regulation of the hair cycle

27 citations , January 2020 in “Experimental Dermatology”

Immune cells affect hair growth and could lead to new hair loss treatments.

research New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence

68 citations , April 2012 in “Journal of Investigative Dermatology”

The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.

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community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 47 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community How far are we from a treatment better than finasteride?

in Treatment 129 upvotes 1 year ago

Dutasteride is more effective than finasteride for hair loss as it blocks more of the enzyme causing hair loss. New treatments like stem cell therapies and alternatives to minoxidil are being explored, but major advancements are still years away.

community Clearing the air on how non-surgical treatments really work

15 upvotes 7 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 66 upvotes 9 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Fats on your Head to Stop Hair Loss?

in Research/Science 140 upvotes 2 years ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

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