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GlossaryStem Cell Plasticity

ability of stem cells to become different cell types

Stem cell plasticity, also known as stem cell flexibility or adaptability, refers to the ability of stem cells to differentiate into a variety of cell types beyond their original lineage. For example, a stem cell from the bone marrow, which typically produces blood cells, might be able to transform into a nerve cell or a muscle cell under certain conditions. This characteristic is crucial for regenerative medicine and therapies aimed at repairing damaged tissues or treating diseases like alopecia, where hair follicle stem cells might be harnessed to regenerate hair.

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research Stem cell dynamics, migration and plasticity during wound healing

211 citations , November 2018 in “Nature Cell Biology”

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

research Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells

3 citations , July 2017 in “Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model”

Mouse hair follicle stem cells have a flexible chromatin state that supports skin health and hair growth.

research Stem Cell Heterogeneity and Plasticity in Epithelia

129 citations , May 2015 in “Cell Stem Cell”

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

research Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer

124 citations , February 2018 in “Nature Reviews Genetics”

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

research Stem cell plasticity enables hair regeneration following Lgr5+ cell loss

56 citations , May 2017 in “Nature Cell Biology”

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

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community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

in Research/Science 48 upvotes 6 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community Possible transgenerational effects of finasteride use on male offspring? (STUDY)

in Research/Science 27 upvotes 3 months ago

Finasteride may affect male offspring's fertility and hormonal balance, with debates on whether to discontinue use before conception. Some users report no issues, while others highlight the high doses used in rat studies.

community My way to recovery and advice - Hope this helps (m20)

in Product 6 upvotes 1 year ago

A 20-year-old shared their experience of reversing hair loss without using minoxidil or finasteride, instead relying on supplements like biotin, collagen, fish oil, saw palmetto, and various vitamins. They emphasized the importance of a balanced supplement schedule and noted improvements in hair health without experiencing additional shedding.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community Lion Mane Part 2: Microneedling with Topicals, beneficial compounds, maybe?

in Microneedling 1 upvotes 2 years ago

The conversation discusses microneedling techniques and the use of Minoxidil, copper peptides, EGF, FGF, ceramides, and hydration serums to enhance hair growth. It explores optimizing scalp conditions and the potential benefits of various compounds in conjunction with microneedling.

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