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GlossaryCell Signaling Proteins

molecules that transmit signals within and between cells

Cell signaling proteins, also known as signaling proteins or signal transduction proteins, are molecules that help cells communicate with each other and respond to their environment. They play a crucial role in transmitting signals from the cell surface to the interior, triggering various cellular responses such as growth, division, or apoptosis. These proteins are essential for maintaining normal cellular functions and can be involved in pathways that affect hair growth and conditions like alopecia.

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Research

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research Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways

3 citations , September 2024 in “International Journal of Molecular Sciences”

Mathematical modeling helps understand and predict the MAPK cell signaling pathway.

research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

176 citations , September 2006 in “Stem Cells”

BMP signaling prevents hair growth by stopping stem cell activation.

research The Stem Cell Quiescence and Niche Signaling is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse.

October 2021 in “Research Square (Research Square)”

Hair follicle stem cells in hairpoor mice are disrupted, causing hair loss.

research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

74 citations , September 2006 in “Cell Cycle”

The HR protein's role as a repressor is essential for controlling hair growth.

research The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse

2 citations , May 2022 in “Stem cell research & therapy”

Disrupted stem cell signals in hairpoor mice cause hair loss.

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Community Join

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community Korean scientists breakthrough in hair regeneration targeting CXXC5 protein and WNT Signaling Pathway

54 upvotes 8 years ago

A potential non-invasive topical treatment targeting the WNT Signaling Pathway for hair regeneration is being researched, with positive results on human hair follicle cells. Current effective treatments for hair loss include Minoxidil, finasteride, and hair transplantation.

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

in Research/Science 145 upvotes 4 months ago

Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.

community Mallia Aesthetics achieves key regulatory steps for novel sCD83-derived ingredient for hair growth

in Research/Science 25 upvotes 11 months ago

Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulates hair growth without disrupting the skin microbiome. sCD83 promotes hair growth by activating hair follicles and preventing cell death, offering a localized treatment without systemic side effects.

community Why does this industry still revolve around 5-AR inhibitors?

in Research/Science 44 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 3 years ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

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