Alpha-ketoglutaric acid (AKG) is highlighted as a promising agent for treating aging and age-related diseases, with potential applications in dermatology and cosmetology. The analysis of scientific literature over the past 25 years indicates that AKG is involved in various cellular metabolic pathways, serving as an energy donor, precursor of amino acid biosynthesis, and epigenetic regulator. It plays roles in regulating immunity, oxidative stress, and preventing aging. Studies have demonstrated AKG's effectiveness in addressing age-related conditions such as osteoporosis, sarcopenia, neurodegenerative diseases, and metabolic disorders. Additionally, AKG may help reduce facial wrinkles and prevent hair loss, as evidenced by experiments on animals.
Different stem cells are key for hair growth and health, and understanding their regulation could help treat hair loss.
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May 2025 in “Nutrition & Metabolism” Metabolic syndrome is linked to skin diseases, requiring integrated treatment and monitoring.
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January 2013 in “International Society of Hair Restoration Surgery” Proper cell preservation is crucial for successful hair transplants and other medical treatments.
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April 2016 in “CRC Press eBooks” Skin aging reflects overall body aging and can indicate internal health conditions.