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research Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

237 citations , February 2016 in “Science Translational Medicine”

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

research Hair test reveals plasticity of human chronotype

March 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

HairTime can predict and adjust human sleep patterns using a hair sample.

research Stem cells and the circadian clock

75 citations , September 2017 in “Developmental biology”

The circadian clock influences the behavior and regeneration of stem cells in the body.

research Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

221 citations , July 2012 in “Proceedings of the National Academy of Sciences of the United States of America”

BMAL1 controls skin cell growth and UV damage risk, peaking at night.

research Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

116 citations , May 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

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community Why I Take 5mg Minoxidil at Night Instead of Splitting 2.5mg

in Minoxidil 10 upvotes 2 months ago

Taking 5mg oral minoxidil at night instead of splitting 2.5mg doses, with the rationale that a single larger dose may provide a stronger activation for hair follicles and reduce peak-related side effects. Some users report sleep issues with nighttime dosing, while others find it beneficial; opinions on effectiveness and side effects vary.

community My Theory Of Androgenic Alopecia

in Research/Science 18 upvotes 8 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 2 years ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.

community Circadian rhythm disruption and its potential impact on hair growth cycles

in Technology 7 upvotes 3 months ago

Poor sleep quality may affect hair growth cycles by disrupting the body's natural clock and stress hormones. The focus should be on improving sleep to support overall health, including hair growth, rather than relying solely on treatments like Minoxidil, finasteride, or RU58841.

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Circadian RejuvenationFayetteville, NC · US

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