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GlossaryCollagenase

enzyme that degrades collagen in tissues

Collagenase is an enzyme that breaks down collagen, a key structural protein in the skin, bones, and connective tissues. This enzyme is crucial in processes like wound healing and tissue remodeling, as it helps to remove damaged collagen and make way for new tissue formation.

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Research

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research Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression

27 citations , September 2015 in “Drug Design Development and Therapy”

Collagenase IV is crucial for hair growth by affecting key growth factors.

research Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression.

26 citations , January 2015 in “PubMed”

Collagenase IV helps control hair growth by affecting certain growth factors.

research Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination

56 citations , December 1990 in “Differentiation”

Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.

research Expression of the Orphan Protein Plet-1 during Trichilemmal Differentiation of Anagen Hair Follicles

30 citations , February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Plet-1 protein helps hair follicle cells move and stick to tissues.

research Expression of extracellular matrix in hair follicle mesenchyme in alopecia areata

11 citations , December 1990 in “British Journal of Dermatology”

Alopecia areata may involve disrupted mesenchymal function in hair follicles.

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community My Personal experience and Success with the Big 3[8-9 Months]

14 upvotes 10 years ago

The user experienced significant hair regrowth and thickening using Minoxidil, Finasteride, and Regenepure DR. They reported no major side effects except for an itchy scalp.

community 21M - 8 months on oral minoxidil, crown still thinning. Considering fin - thoughts?

in Finasteride/Dutasteride 9 upvotes 3 months ago

The conversation suggests starting finasteride or dutasteride alongside minoxidil for better hair loss treatment, as minoxidil alone is seen as ineffective without a DHT blocker. Some users also mention considering RU58841 as an alternative to finasteride.

community Comprehensive Microneedling Guide

in Microneedling 290 upvotes 3 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

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