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A Randomized Phase II Trial on the Addition of Dutasteride to Combined Androgen Blockade Therapy Versus Combined Androgen Blockade Therapy Alone in Patients with Advanced or Metastatic Salivary Duct Carcinoma – The DUCT Study Protocol

research A randomized phase II trial on the addition of dutasteride to combined androgen blockade therapy versus combined androgen blockade therapy alone in patients with advanced or metastatic salivary duct carcinoma – the DUCT study protocol

4 citations , September 2024 in “BMC Cancer”

Adding dutasteride to therapy may improve treatment for advanced salivary duct cancer.

research Is dehydroepiandrosterone a hormone?

403 citations , November 2005 in “Journal of Endocrinology”

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

research COMBINATION OF AN ANTIANDROGEN AND A 5α-REDUCTASE INHIBITOR: A FURTHER STEP TOWARDS TOTAL ANDROGEN BLOCKADE?

9 citations , March 1991 in “Endocrinology”

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

research Androgenetic alopecia: An autosomal dominant disorder

80 citations , January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

research Androgen excess: Investigations and management

82 citations , May 2016 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

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Community Join

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community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 133 upvotes 2 years ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community so what do you guys think of Cosmerna + Ru or pyri ?

in Research/Science 10 upvotes 3 years ago

Hair loss treatments Cosmerna, RU, and Pyri discussed. Cosmerna inhibits androgen receptors, but not 100%, so RU/Pyri can be used synergistically.

community PP405 (Everychem 3HP) Anecdotes - Please assemble and share your story

in Chat 107 upvotes 3 months ago

PP405 (Everychem 3HP) may help with hair regrowth, with mixed user experiences. Users often combine it with minoxidil and finasteride, but there are concerns about its efficacy and side effects.

community New Latanoprost-Based Formula Used by Hollywood Celebrities

in Treatment 26 upvotes 3 years ago

A new Latanoprost-based formula used by Hollywood celebrities to treat hair loss, with the formula containing minoxidil, tretinoin, melatonin, azelaic acid, zinc thymulin, vitamin B6, sandalore and methyl vanillate. It also mentions the potential of offering a combined sublingual minoxidil/oral dutasteride option in the future.

community Suffering from success. So much hair now that i need to tie it up to keep it out my eyes. 16ish months.

in Progress Pictures 1193 upvotes 1 year ago

The user experienced significant hair regrowth using minoxidil, microneedling, and estrogen, leading to a need to tie their hair back. They attribute the success to estrogen suppressing testosterone, alongside their routine of minoxidil, microneedling, and supplements.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

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