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Dissecting the Role of the Common Neurotrophin Receptor CD271 in the Skin: Generation and Characterization of a Novel Mouse Model with Keratinocyte-Specific Conditional Deletion

research 186 Dissecting the role of the common neurotrophin receptor CD271 in the skin: generation and characterization of a novel mouse model with keratinocyte-specific conditional deletion

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Deleting the CD271 gene in mouse skin cells leads to disorganized skin and increased hair growth, suggesting CD271 is important for skin health.

research Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage

210 citations , May 2006 in “The FASEB journal”

Oxidative stress causes hair to gray by damaging and killing pigment cells.

research Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

23 citations , October 2021 in “Cell Stem Cell”

Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.

research Compartmentalized organization: a common and required feature of stem cell niches?

63 citations , April 2010 in “Development”

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

research Selection signatures in goats reveal a novel deletion mutant underlying cashmere yield and diameter

November 2022 in “Gigascience”

A specific genetic deletion in goats affects cashmere yield and thickness.

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community Low-dose oral minoxidil and skin aging

in Minoxidil 6 upvotes 7 years ago

The conversation discusses the use of low-dose oral minoxidil for hair loss and its potential effects on skin aging. Users shared experiences, with some noting side effects like puffy eyelids and dark circles, but no conclusive evidence of significant collagen depletion or increased wrinkles.

community 9 months on fin and oral minoxidil (26M)

in Progress Pictures 2324 upvotes 2 years ago

A user shared their positive experience with hair regrowth after 9 months of using 1mg finasteride daily and 2.5mg oral minoxidil every other day, with no side effects. Other users expressed various reactions, from skepticism to hope, and discussed their own experiences with similar treatments.

community 7 months oral fin 1 mg once daily, 3 months min 5% once daily same length, same angle, same lighting

in Progress Pictures 306 upvotes 2 years ago

The post and conversation are about a user's progress in treating hair loss using oral finasteride and topical minoxidil. The user expresses regret for not starting treatment earlier.

community 12 mo fin. 3 mo Min. time for me to leave the subreddit.

in Progress Pictures 697 upvotes 4 years ago

A user sharing their hair restoration results after taking finasteride for 12 months and minoxidil orally for 3 months; other users responding with questions and comments about the treatments used.

community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 1 year ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

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