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      community Female on DHT blockers, need some advice.

      in Research/Science  4 upvotes 8 months ago
      A female experiencing hair loss while on testosterone replacement therapy is using oral Minoxidil, Spironolactone, and finasteride, but still losing hair. Suggestions include switching to dutasteride, using topical anti-androgens, and reducing Nizoral shampoo use to prevent scalp dryness.

      community My Near-Nuclear Stack is Saving me; Hyperresponder?

      in Progress Pictures 1 year ago
      An 18-year-old is using a high-dose hair loss treatment regimen including finasteride, minoxidil, dutasteride, and plans to add RU58841 and bimatoprost, despite warnings from others about the risks. The user is determined to reverse hair loss but acknowledges the potential dangers and does not recommend others follow their approach.

      community Anyone hear of Ursolic Acid?

      in Question  4 upvotes 7 years ago
      Ursolic acid, found in apple peels, lemongrass, rosemary, and lavender, may have anti-androgen effects similar to finasteride. It might be beneficial for hair health when used with other treatments like Minoxidil, Finasteride, and RU58841.

      community 2 Months Ru58841+Min Progress at 17

      in Progress Pictures  60 upvotes 8 months ago
      A 17-year-old shared progress pictures after using RU58841 and Minoxidil for 2 months, showing significant hair regrowth. Another user commented on the impressive results achieved in a short time.

      community Androgen degraders for hair loss

      in Research/Science  61 upvotes 1 year ago
      The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 year ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community 6 month transformation from fin to dut+min+ru

      in Progress Pictures  102 upvotes 6 months ago
      A 30-year-old male switched from finasteride to a combination of dutasteride, oral minoxidil, and RU58841, achieving significant hair growth without side effects. He plans to add GHK-Cu peptide to his regimen for further improvement.

      community Extreme caution: my experience using Ru58841 only once

      in Treatment  10 upvotes 1 year ago
      An 18-year-old experienced severe side effects, including heart palpitations and high blood pressure, after using RU58841 once, leading to a referral to cardiology for suspected left ventricular hypertrophy. The user regrets using RU58841 and seeks advice on recovery, while others suggest preexisting conditions or genetic predispositions may be factors.

      community Possible solution: 2.5mg DUT for everyone

      in Chat  13 upvotes 1 year ago
      A user is experimenting with creating a DIY oral Dutasteride solution using raw powder, MCT oil, and Vitamin E to reduce costs. Others discuss their experiences with similar methods and the challenges of sourcing and testing Dutasteride.

      community 0.25mg Fin every day, 2 months status report

      in Finasteride/Dutasteride  10 upvotes 4 years ago
      A user reported increased shedding and some side effects like ball ache and potential watery semen after taking 0.25mg of finasteride daily for two months, but noted a high sex drive and considered the shedding a possible sign of new hair growth. Other users discussed dosage differences, with some suggesting starting with a smaller dose and monitoring effects, while others shared their experiences with no shedding or hair growth yet.

      community Just checked my hormones before starting Fin

      in Finasteride/Dutasteride  6 upvotes 1 year ago
      A user is considering starting finasteride for hair loss and shares their hormone levels, with others suggesting checking SHBG and discussing potential side effects. Some recommend starting with 0.5 mg finasteride, while others suggest considering dutasteride.

      community Effect of melatonin on aromatase expression

      in Update  5 upvotes 4 years ago
      Melatonin's effect on aromatase expression is unclear, with studies showing both increases and decreases. Hormonal impacts are complex and inconsistent, similar to changing health advice on other substances.

      community Does the PG-free version of RU58841 have lower absorption compared to the PG version?

      in Chat  5 upvotes 8 months ago
      The conversation discusses the absorption and effectiveness of PG-free versus PG versions of RU58841, with some users believing PG improves efficacy while others see no difference. Concerns about RU58841's potential side effects on the endocrine system are also mentioned, with one user considering switching to pyrilutamide.

      community Female AGA - Low Cortisol/Low DHEA

      in Female  6 upvotes 3 years ago
      Female (37) experiencing hair loss for 5 years, tried max dose of spiro and oral + topical minox without success. Discovered low cortisol and low DHEA levels, seeking functional medicine practitioner for help.

      community Spironolactone, what do you think?

      in Finasteride/Dutasteride  4 upvotes 1 year ago
      A user is considering Spironolactone for hair loss but is advised against it due to its effects on testosterone. Instead, they are recommended to try finasteride at 18 and consider dutasteride if needed.

      community Anyone who used RU58841 without fin/dut?

      in Product  1 upvotes 1 year ago
      RU58841 was used by some for hair loss, but concerns about side effects like gynecomastia and safety were raised. Alternatives like finasteride, minoxidil, pyrilutamide, and alfatradiol were discussed, with some users reporting better experiences with these treatments.

      community 7 months progress, 20M, 1.25mg finasteride

      in Progress Pictures  400 upvotes 2 months ago
      A 20-year-old has been using 1.25mg finasteride daily and 5% minoxidil twice a day for seven months with no side effects, noticing thicker hair but no reversal of hairline recession. Users discuss the effectiveness of finasteride and minoxidil, with some mentioning additional treatments like derma rolling and lifestyle changes.
      104 days of .5mg dut at 17 (read desc)

      community 104 days of .5mg dut at 17 (read desc)

      in Journals / Progress Pictures  81 upvotes 11 months ago
      The user has been using oral Dutasteride (.5mg) for 104 days and oral Minoxidil (.5mg) for about 2 months to address hair loss. Changes in hair appearance are noted, influenced by haircuts and dyeing, which affect the visibility of thinning areas.

      community 17M with Diffuse Thinning, Dandruff, and Body Hair Shedding

      in Basic Questions  93 upvotes 1 month ago
      A 17-year-old is experiencing diffuse thinning, dandruff, body hair shedding, and other symptoms, possibly linked to seborrheic dermatitis or telogen effluvium. They are using ketoconazole shampoo and considering blood tests to check for thyroid issues or deficiencies.

      community Are these all the anti androgen products?

      in Treatment  6 upvotes 2 years ago
      The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

      community blood DHT levels shot up after doubling dutasteride dosage

      in Finasteride/Dutasteride  20 upvotes 2 years ago
      A user increased their dutasteride dosage from 0.5mg to 1mg daily, resulting in a rise in DHT levels from 148 pg/mL to 281 pg/mL, and is considering switching back to finasteride due to continued hair loss. Replies suggest retesting and emphasize the importance of bloodwork before starting treatments.