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The conversation humorously criticizes The Beatles for having more hair in old age than the user at 20. It includes mentions of finasteride and dutasteride as hair loss treatments.

A 22-year-old man shared his experience with hair loss, which began at age 20, and his treatment with finasteride and oral minoxidil, planning to add microneedling. Since experiencing hair loss, he has changed his perspective and now notices other men's hair loss more, viewing them positively, and others in the conversation relate to this shift in perception.

The user has been using finasteride for 18 months, minoxidil for 20 months, and recently added tretinoin, nizoral, and dermarolling to their hair loss treatment without success. They are seeking new suggestions for treating persistent hair fall and thinning.

The user is considering using topical dutasteride to prevent hair loss progression from Norwood 1 to Norwood 2 at age 25, and is concerned about the long-term effectiveness and potential shedding from the treatment. They are currently using a shampoo with caffeine, rosemary, and saw palmetto, and have noticed hair thinning and changes since age 20.

TurboMoe has been using 1mg finasteride and 2mL minoxidil daily for 6 months to reverse his frontal hair loss, with good results. He previously used finasteride in his 20's but stopped before having children due to low sperm count; he stayed off it until his last child was born.

Homemade topical finasteride solutions are discussed, with one user using 30% ethanol, 50% propylene glycol, and 20% water. Alternatives like dissolving finasteride pills in minoxidil and using stemoxydine are also mentioned.

Long-term finasteride users report maintaining hair and experiencing regrowth, with some using it for over 20 years. Combining finasteride with minoxidil or hair transplants can improve results.

Stemson raised $15M for hair cloning, with hopes it becomes a reality in 10-20 years. Users are hopeful and discuss using Minoxidil and finasteride in the meantime.

Hair cloning is unlikely to be available soon, with estimates ranging from 10 to 20 years away. Current treatments like Minoxidil, finasteride, and RU58841 are still the main options.

A 16-year-old is experiencing severe hair thinning and wants to start finasteride but is advised to wait until at least 20. In the meantime, minoxidil is suggested as an alternative.

A user shared their hair loss journey, starting treatments with topical minoxidil and finasteride at 17, and later adding oral versions and dutasteride by age 20, but still experiencing hair loss. Others suggested that the treatments have likely slowed the progression, and some recommended considering a hair transplant or adjusting medication, while expressing concerns about the potential side effects of starting such treatments at a young age.

The user experienced significant hair loss after stopping a treatment with vitamins, minoxidil (2.5mg), and dutasteride (0.5mg) for three months. They resumed the treatment 20 days ago and are hopeful for recovery, with no side effects reported.

The conversation discusses creating a topical catalase solution with phosphate buffered saline, glycerin, and polysorbate 20 for hair loss treatment. The user seeks advice on preparing this solution.

Hair regeneration and follicle cloning are considered far from being feasible, with current treatments like finasteride, minoxidil, and hair transplants expected to remain dominant for the next 15-20 years. Some are hopeful that AI advancements might accelerate progress, but many remain skeptical about significant breakthroughs in the near future.

Combining topical minoxidil and pyrilutamide (KX-826) for hair loss treatment. It is suggested to apply minoxidil first, wait 20 minutes, then apply pyrilutamide for better absorption.

Mixing 2.5mg of minoxidil powder with 150ml of water seems to eliminate its blood pressure effects, causing only a brief 20-second hypertension. The reason for this effect is unclear.

PP405 is moving to late-stage trials, showing potential for hair regrowth, with 31% of male patients experiencing a 20% increase in hair density. Veradermics is developing an oral minoxidil version, and there is interest in combining treatments for better results.

A 60-year-old man experienced significant hair regrowth over four months using a topical solution with finasteride 0.3% and minoxidil 6%. The progress is impressive, especially given his 20-year history of a bald spot.

A new hair loss treatment, PP405, showed promising Phase 2a results with 31% of patients experiencing over 20% hair density increase without systemic absorption, avoiding hormonal side effects. The treatment is expected to be expensive, with Phase 3 trials starting mid-2026, and there is skepticism about the data's strength.

The user experienced hair repigmentation and attributes improvements in hair and overall health to a carnivore diet, Boron, and Selenium supplementation. They stopped using finasteride after 20 years, noticed increased testosterone and libido, and observed hair regrowth with RU58841.

Pelage Pharmaceutical raised $120 million to continue research on PP405, a promising hair loss treatment that showed a 20% increase in hair density in 31% of men during a Phase 2a trial. The treatment was well-tolerated, with no systemic absorption, and Phase 3 trials are planned for 2026.

Switching from finasteride and minoxidil to dutasteride and minoxidil can potentially lead to over 40% improvement in hair thickness in some cases, especially in young individuals who have plateaued after initial success. Generally, a 20% improvement is expected after six months.

The conversation discusses potential hair loss treatments focusing on stimulating IGF-1 at the follicle level using growth-factor cocktails and engineered peptides, such as Acetyl Tetrapeptide-3, Copper Tripeptide-1, Oligopeptide-20, Thymosin-β4, and Palmitoyl Tetrapeptide-7. It suggests that device-assisted delivery methods like microneedling may enhance effectiveness.

An 18-year-old in India is seeking a dutasteride prescription for aggressive hair loss, as family members are bald by age 20. Local doctors advised against it, so they are considering using Indian telemedicine apps for a prescription.

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

PP405 shows significantly better early-stage hair regrowth results compared to minoxidil and finasteride, with 31% of users experiencing over 20% density increase in 4–8 weeks. Minoxidil and finasteride show minimal or no visible regrowth in the same timeframe.

PP405 is a potential new hair loss treatment that might replace finasteride and minoxidil, but it is still in clinical trials and may not be available until 2028-2031. There is skepticism about its effectiveness, with only a 20% increase in hair density observed in some participants.

The user shared their 21-month hair loss treatment journey using oral finasteride, minoxidil, microneedling, and ketoconazole shampoo, noting visible improvement by months 3-4 and reduced shedding after month 20. They experienced no side effects and emphasized this is based on personal experience, not medical advice.

A 19-year-old with thinning hair at the temples is prescribed finasteride 1mg daily and minoxidil 2% twice daily. They seek feedback on the effectiveness of finasteride for young people, especially those who started between ages 18-20, given their family history of baldness.

The user has been using oral finasteride 1mg and oral minoxidil 2.5mg daily since late 2024 and reports positive progress in hair growth without side effects, though some unwanted hair growth on hands and arms. The user is 26 years old and started losing hair around age 20 or 21.