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Did you mean 5-alpha-reductase inhibitor?

Glossary5-alpha-reductase inhibitor

blocks enzyme converting testosterone to dihydrotestosterone (DHT)

A 5-alpha-reductase inhibitor is a type of medication that blocks the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). By reducing DHT levels, these inhibitors can help treat conditions like male pattern baldness and benign prostatic hyperplasia (BPH).

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community Did Dutasteride change how you look physically? your facial profile such as skin thickness, fat distribution or softness?

in Finasteride/Dutasteride 51 upvotes 10 months ago

Dutasteride and finasteride can cause changes in physical appearance, like more feminine features and increased water retention. Users report side effects such as reduced libido, weight gain, and improved skin clarity, while some notice no significant changes.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 2 years ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Started Finasteride almost three months ago and I'm upset

in Update 153 upvotes 2 years ago

A user started taking finasteride three months ago to treat hair loss and unexpectedly cleared their acne, which they had been struggling with since age 12. The conversation includes others sharing their experiences with finasteride, its effects on acne and hair loss, and mentions a related treatment, clascoterone, for acne and hair loss.

community Has anyone ever tried using (all topicals) finasteride + minoxidil + rosemary oil + castor oil + stemoxydine all over the course of a few months/years?

in Treatment 3 upvotes 2 years ago

The user is using topical finasteride and minoxidil for hair loss and is considering adding rosemary oil, castor oil, and stemoxydine to their routine. They are asking if anyone has experience with this combination or a similar one.

community blood DHT levels shot up after doubling dutasteride dosage

in Finasteride/Dutasteride 20 upvotes 2 years ago

A user increased their dutasteride dosage from 0.5mg to 1mg daily, resulting in a rise in DHT levels from 148 pg/mL to 281 pg/mL, and is considering switching back to finasteride due to continued hair loss. Replies suggest retesting and emphasize the importance of bloodwork before starting treatments.

community (27M) Seems like first PRP session just worsen my hair...

in Progress Pictures 4 months ago

A user experienced worsened hair condition after a PRP session and is considering stopping further sessions. They are using a Dermapen, electric massage, iron, saw palmetto, and plan to start minoxidil, but have had side effects with finasteride and are advised to consider dutasteride under medical supervision.

community [M19] five months progress on fin+ oral minoxidil

in Progress Pictures 34 upvotes 3 years ago

User reports five months progress on finasteride and oral minoxidil, with thicker hair and no visible scalp. Started at 2.50mg and increased to 10mg without side effects.

community Microneedling + Min 2 months progress

in Progress Pictures 1068 upvotes 2 years ago

The post and conversation are about a user's progress with microneedling and minoxidil for hair loss. The user is happy with the progress and plans to continue with the treatment, without using finasteride.

community I interviewed Kintor: GT20029 Clinical Trial Pictures. As well as KX826.

in Research/Science 156 upvotes 1 year ago

GT20029 and KX826 are promising hair loss treatments, with GT20029 increasing hair count and KX826 showing significant results. KX826 may be a good alternative for those who can't use finasteride or dutasteride, though results vary.

community 8 months on minoxidil and 4.5 months on finasteride

in Update 485 upvotes 3 years ago

Franquito1624: Topical minoxidil and finasteride orally This user, Franquito1624, reported 8 months of using Minoxidil topically and 4.5 months of using Finasteride orally with good results. Other users commented on their success and asked questions about the treatments used.

community What treatment helped you with oily scalp/hair loss?

in Chat 8 upvotes 1 year ago

The user has been dealing with an oily scalp, seborrheic dermatitis, and hair loss for 18 months, using finasteride without improvement. Another user suggested dutasteride for reducing scalp oiliness.

community Approximately 1 month on oral dut+ oral min

in Progress Pictures 103 upvotes 1 year ago

A user shared progress pictures after one month on oral dutasteride and minoxidil, noting some improvement despite initial shedding. They previously used finasteride for a year without noticeable change and emphasized the importance of photo comparisons.

community Update: going nuclear! (Switch to dut)

in Update 13 upvotes 2 months ago

The user had a hair transplant in March 2025 and has been using finasteride since 2023, which halted hair loss but didn't fully restore density. They plan to use dutasteride twice weekly, finasteride five times a week, and saw palmetto to improve hair thickness.

community Does Min Act Differently If MPB Is Not Genetic

in Minoxidil 5 upvotes 1 month ago

The conversation discusses hair loss caused by Trenbolone use, with suggestions to stop using it and consider treatments like Minoxidil, Dutasteride, and RU58841. It highlights that Minoxidil may temporarily regrow hair, but stopping Trenbolone is crucial to prevent further hair loss.

community Anyone else realize how many younger guys are balding?

in Chat 262 upvotes 1 year ago

Many younger men are experiencing hair loss due to genetics, diet, stress, and lifestyle changes. Treatments like finasteride and minoxidil are mentioned, with some users noting improvements.

community 3 Months Pyrilutamide(1.5 Months 1% ) + Alfatradiol 0.1% + Minoxidil

in Treatment 105 upvotes 1 year ago

The conversation discusses using Pyrilutamide, Alfatradiol 0.1%, and Minoxidil for hair loss treatment. Pyrilutamide is described as a strong antiandrogen, and Alfatradiol is noted for its effectiveness in inhibiting DHT on the scalp.

community Need advice with finishing off my hair loss :)

in Treatment 8 upvotes 4 years ago

User is a Norwood 2-2.5, using 1.25 mg finasteride and 5% minoxidil lotion daily since June last year, experiencing significant regrowth. They are considering additional treatments like saw palmetto, microneedling, dutasteride, aminexil, stemoxydine, mesotherapy, ketoconazole shampoo, and alfatradiol to improve hair thickness.

community My Current Stack in 2026 , (not cheap)

in Treatment 12 upvotes 2 weeks ago

OP uses a hair loss treatment stack including dermastamp, Minoxidil 5%, Alfatradiol 0.2%, Pyrilutamide 0.9%, and Nizoral shampoo, costing around 100-110€ monthly. OP avoids finasteride due to past negative experiences.

community Write down your routine to fight agains hair loss

in Chat 16 upvotes 4 years ago

The conversation is about personal routines to combat hair loss, including treatments like Minoxidil, Finasteride, RU58841, vitamins, and dermastamping. Specific methods vary, with some using daily topical applications, oral medications, and weekly procedures like dermarolling and special shampoos.

community Found a Pharmacy that will mix me 0.1 % Alfatradiol (Pantostin)

in Treatment 6 upvotes 1 year ago

The user is currently using 0.025% Pantostin but plans to switch to 0.1% Alfatradiol. They will also use high-dose Kx826, high-dose Minoxidil, and aggressive microneedling for hair regrowth.

community Anyone used the 2% pyrilutamide / KX-826 from anagenica or anywhere else?

in Product 2 upvotes 1 year ago

People are discussing hair loss treatments, including pyrilutamide, minoxidil, dutasteride, alfatradiol, and bimatoprost. Users share their experiences and side effects, noting that pyrilutamide is considered more effective and safer than RU58841.

community Rate my treatment stack from 1-10

in Chat 1 year ago

The conversation discusses various hair loss treatments, with a focus on pyrilutamide, minoxidil, and alternatives to finasteride due to intolerance. Users suggest adding a DHT blocker like finasteride or dutasteride, and some recommend trying topical versions to reduce side effects.

community High Dose 0.1% Alfatradiol + 1% Pyrilutamide stopped my Hairloss completely

in Treatment 33 upvotes 1 year ago

Using 0.1% Alfatradiol and 1% Pyrilutamide stopped hair loss, reducing shedding from over 150 hairs a day to less than 10, with no side effects. The user also uses Minoxidil and microneedling, applying the treatments twice daily.

community Non-Fin Super Regimen (Fluridil, Min, Stem, Niz, Viviscal, Broccoli Sprouts, Derma)

in Product 15 upvotes 4 years ago

Hair loss treatments discussed include Fluridil, Minoxidil, Stem, Niz, Viviscal, Broccoli Sprouts, and Derma. One user claims most treatments are ineffective, while another supports Eucapil.

community Megadosing Koshine826(Pyrilutamide), my Plan.

in Treatment 1 upvotes 1 year ago

The user plans to use 1% Koshine826, 0.1% Alfatradiol, Minoxidil with Tretinoin, microneedling, and Stemoxydine for hair loss treatment. They expect significant recovery with this regimen.

community Why I believe alfatrodial and fluridil combined with minoxidil is an effective treatment. My experience.

in Research/Science 11 upvotes 1 year ago

The user believes that combining alfatrodial and fluridil with minoxidil effectively maintains hair, based on their 7-year experience. They suggest this combination for those who can't tolerate finasteride.

community Is Fluridil truly void of side effects?

in Chat 5 upvotes 4 years ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. User considers trying Fluridil, questioning if it has no side effects.

community MinoxidilMax just launched a 0.3% tretinoin topical. Would you try?

in Treatment 15 upvotes 4 years ago

The conversation discusses a new 0.3% tretinoin topical launched by MinoxidilMax for mixing with other solutions, with some users expressing concern about potential skin irritation compared to lower concentrations. MinoxidilMax has also released other products like topical Dutasteride and RU58841.

community Anyone immediately lose hope for gt20029 when they realised it’s developed by kintor

in Research/Science 7 upvotes 5 months ago

The conversation discusses various hair loss treatments, including minoxidil, finasteride, dutasteride, pyrilutamide, alfatrodial, and nizoral, with a focus on the potential of new treatments like gt20029 and breezula. There is optimism about novel treatments that don't have systemic effects, although skepticism remains about the effectiveness of some new drugs.

community Is Finasteride the only way to reduce scalp DHT?

in Chat 28 upvotes 7 months ago

A 24-year-old male experienced side effects like low libido and ED after starting finasteride post-hair transplant and is seeking alternatives to reduce scalp DHT. Suggestions include topical finasteride, Xpecia, DHT-reducing shampoos, and switching to dutasteride, with some users reporting fewer side effects with these alternatives.