PP405 is a promising new treatment for hair loss that activates dormant stem cells in hair follicles, potentially bypassing the effects of DHT. It is currently in phase 2 trials and could be available between 2027 and 2030, but it is not considered a definitive cure.
Accutane may accelerate hair loss in genetically predisposed individuals by affecting enzymes related to DHT metabolism. Some users report hair loss after taking Accutane, while others use treatments like finasteride and minoxidil to manage hair loss.
A manager told an employee to stop using minoxidil, fearing it could unintentionally cause hair growth in others. The conversation is filled with humorous and sarcastic responses, questioning the manager's logic and suggesting the employee continue using the treatment secretly.
Finasteride and dutasteride may not significantly impact meibomian gland function since these glands do not rely on DHT. Some users report dry eyes and other side effects from finasteride, but these may be influenced by other factors or medications.
The user switched from finasteride to dutasteride and experienced noticeable hair regrowth without side effects, though some users questioned the necessity of such a potent treatment given the minimal hair loss. The conversation also touched on potential side effects of dutasteride, such as reduced sperm quality, but the user reported no issues.
The conversation discusses alternatives to 5AR inhibitors for hair loss treatment, suggesting options like minoxidil, KX-826, pyrilutimide, microneedling, and topical bicalutamide. Concerns about side effects and the effectiveness of these treatments are also highlighted.
The user switched from finasteride to dutasteride due to a prostate condition and noticed mixed results, with some improvement in the middle hairline but worsening at the temples, while also using minoxidil. Other users shared similar experiences with shedding and emphasized the need for patience, as dutasteride can take several months to show full effects.
The user started finasteride in April 2024 after experiencing hair thinning and had been using minoxidil since January 2023. They report significant hair recovery with no side effects from finasteride, and they continue to use both treatments together.
Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.
Folliculitis may be linked to hair loss, with treatments including antibiotics, minoxidil, finasteride, and dietary changes. Users suggest seeing a dermatologist for proper diagnosis and treatment.
Finasteride and Dutasteride do not cause dry eyes by damaging meibomian glands, as these glands continue to function normally even when DHT is blocked. Some users report dry eyes with these medications, but others suggest supplements like Omega-3 or krill oil as potential remedies.
The conversation discusses hair loss treatments, specifically the use of minoxidil and dermarolling, with suggestions to add finasteride for better long-term results. The user shares progress after two months of using topical minoxidil twice daily and dermarolling once a week, while considering starting finasteride.
A 25-year-old saw no improvement in hair loss after using finasteride for a year and oral minoxidil for six months. Alternatives like dutasteride, microneedling, and topical treatments were suggested, but results vary.
A 27-year-old user shared their 5-month progress using 1mg finasteride daily and 5% minoxidil twice a day for hair loss, reporting improved hair growth despite initial shedding and experiencing only minor side effects like watery semen. They also use Nizoral shampoo, take a multivitamin, and plan to start microneedling if progress slows.
A user shared their hair loss treatment journey, using topical Minoxidil, Finasteride, Tretinoin, and Stemoxydine, and asked for feedback on progress after one month. Responses varied, with some users suggesting patience and consistency, while others noted minimal visible change.
Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.
The user experienced hair thinning and used microneedling, DHT blocking shampoo, and Biotin DHT blocking oil to address it, avoiding finasteride and minoxidil unless necessary later. They reported mild improvement but received mixed feedback, with some suggesting other conditions or treatments like ciclopirox shampoo.
A 21-year-old experiencing significant hair loss despite using dutasteride, oral minoxidil, ketoconazole shampoo, and low-level laser therapy seeks advice. Suggestions include adding microneedling, checking for vitamin deficiencies or thyroid issues, and considering a scalp biopsy for other conditions.
A user is experimenting with a homemade solution of WAY-316606 for hair regrowth, combining it with other treatments like minoxidil and dutasteride. The community expresses concern over the safety and mental health implications of such drastic measures, with mixed opinions on the effectiveness of WAY-316606.
The user switched from finasteride to dutasteride for hair loss but faced increased shedding and anxiety, regretting not staying with finasteride longer. Other users shared mixed experiences, advising patience with dutasteride, as it may take up to a year to show results.
Hair loss treatments like finasteride, minoxidil, and dutasteride are popular but often lead to side effects and mixed results. The discussion stresses consulting medical professionals and being wary of unproven treatments in the hair loss industry.
The user has used minoxidil for five years and added microneedling for four weeks without seeing results. They are considering a hair transplant but are advised that hair loss will persist without a DHT blocker.
Finasteride and dutasteride may increase estrogen levels, leading to water retention and a fuller face. Users discuss managing these effects with lifestyle changes and supplements like zinc and DIM.
Finasteride effectively regrew hair and improved quality after increasing the dose from 0.5mg to 1mg, with no side effects. The user is cautious about adding minoxidil, fearing it might disrupt progress.
Long aerobic exercise (over 60 minutes) can reduce DHT levels and improve hair health. Some users discuss using Tadalafil (Cialis) to further reduce DHT after exercise, while others mention using treatments like Minoxidil, Finasteride, and RU58841 for hair growth.
Intense microneedling with heavy pressure and bleeding did not improve hair growth after 4 months. The user advises against this method, noting no benefits and potential harm, and mentions using minoxidil without success.
The user is experiencing hair regrowth using finasteride, minoxidil, and KX-826. They regret not starting treatment earlier but are now seeing progress.
A user started using oral minoxidil (2.5 mg) and dutasteride (1 mg) for hair loss three months ago and noticed no side effects, possibly due to regular exercise. They speculate a possible link between COVID-19 and accelerated hair loss.
Chlorine dioxide was discussed as a potential hair growth treatment, with a method involving spraying it on the scalp and covering it with a cap. Concerns were raised about its safety, comparing it to bleach.