DHT may inhibit hairgrowth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hairgrowth by altering metabolic pathways, potentially counteracting DHT's effects.
PP405 shows potential for hairgrowth, with 31% of advanced balding men experiencing over 20% increase in hair density in 8 weeks. However, skepticism persists due to selective data presentation and lack of long-term results, with comparisons to treatments like minoxidil and finasteride.
Topical sodium valproate may promote hairgrowth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.
A user shared positive hairgrowth results using finasteride, minoxidil, ketoconazole shampoo, and vitamin supplements over 7 to 11 months. They discussed application tips and side effects with others.
PP405 shows promising results for hairgrowth, potentially outperforming finasteride without side effects like erectile dysfunction. Users discuss using treatments like minoxidil, pyrilutamide, nizoral, and alfatradiol while waiting for PP405's availability.
P-1075 is a more potent hairgrowth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.
The user experienced positive hairgrowth results using microneedling with rosemary and mint oil, without Minoxidil, Finasteride, or RU58841. They switched from a dermaroller to a microneedling pen and targeted different scalp areas weekly.
The user shared progress pictures showing hairgrowth after using finasteride 1mg and minoxidil 5% daily for three years. Commenters are impressed, discussing the effectiveness and asking about additional treatments like derma rolling and side effects.
Rosemary water's effectiveness for hairgrowth is debated, with some users suggesting medications like minoxidil combined with tretinoin for better results. Others argue rosemary oil may work with continuous use, but evidence is questioned.
A user has been using Waterman's Grow Me Shampoo, which claims to have DHT blockers and promote hairgrowth. They've noticed potentially faster hairgrowth and some new hairs but are unsure if the product is effective or not.
A physician experienced hair thickening and new growth using microneedling and minoxidil, but stopped using topical finasteride due to side effects like reduced libido and erectile dysfunction. The physician plans to continue with microneedling and minoxidil, considering finasteride nonessential for cosmetic purposes.
Androgenetic alopecia is caused by DHT affecting hairgrowth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hairgrowth.
A 24-year-old experienced improved hairgrowth using 5% minoxidil, 1 mg finasteride, and dermastamping, but faced side effects like low libido and mild erectile dysfunction. They plan to reduce finasteride dosage after full results and may consider a hair transplant if thinning recurs.
Combining minoxidil with tretinoin appears to enhance hairgrowth for some users, with several reporting better results than using minoxidil alone. Some users also incorporate other treatments like dutasteride, latanoprost, and microneedling for improved outcomes.
Creatine may counteract minoxidil's hairgrowth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.
Finasteride use resulted in increased hairgrowth but reduced libido for some, leading users to consider topical versions to lessen side effects. Opinions varied on the trade-off between hair benefits and sexual side effects.
Oral minoxidil can increase body hairgrowth, but effects differ among individuals. Some recommend topical minoxidil to prevent unwanted body hair while preserving scalp hair.
Microneedling with minoxidil significantly boosts hairgrowth, even for non-responders to minoxidil alone. The routine includes a 1.5mm dermaroller weekly and minoxidil twice daily, with some users adding finasteride and tretinoin.
A 32-year-old is pleased with hairgrowth results from using oral finasteride (1.2mg) and minoxidil (3mg) without side effects, after switching from topical minoxidil. They report no shedding and increased facial hair density, and they purchase the combo pill from the Hims brand.
PP405 is discussed as a potential hairgrowth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.
Quercetin and houttuynia cordata extract may stimulate hairgrowth by enhancing cellular energy metabolism and increasing growth factor secretion. Quercetin has low oral bioavailability, and its natural tint might stain the scalp if used topically.
PP405 shows promise in stimulating new terminal hairgrowth by activating dormant follicles, with no systemic adverse effects observed in a short-term trial. However, long-term efficacy remains unproven, and further trials are needed to confirm its potential as a hair loss treatment.
Microneedling is discussed as a method to improve hairgrowth, with users sharing their experiences and results using different needle depths and frequencies. Treatments mentioned include minoxidil, finasteride, rosemary oil, and saw palmetto supplements.
Low vitamin D levels can negatively impact hairgrowth, and supplementing with vitamin D, along with treatments like finasteride and minoxidil, may help improve hair health. Quitting smoking and ensuring adequate vitamin B12 and K2 intake are also suggested to support hair regrowth.
Whether topical caffeine can be as effective for hairgrowth as minoxidil and finasteride, with various replies discussing the efficacy of these treatments and criticism of Dr. Huberman's research methods.
User xEternex tries hair regrowth with daily broccoli sprouts, apple extract containing procyanidin b2, and microneedling. Others discuss potential issues with the experiment and share their experiences with vegetable consumption and hairgrowth.
Microneedling may enhance hair loss treatment by increasing the effectiveness of topical minoxidil, especially for those lacking the necessary enzyme to activate it. It might also work by triggering growth factors and improving topical absorption.
Travoprost may be more effective than minoxidil for hairgrowth and can be used alongside it, but its effectiveness is debated due to inconsistent dosing results. Travoprost is expensive and not widely used, with alternatives like latanoprost and bimatoprost being more accessible.
Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hairgrowth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.