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GlossaryAdenocarcinoma

type of cancer originating in glandular epithelial tissue

Adenocarcinoma is a type of cancer that originates in glandular tissue, which is part of the epithelial tissue lining certain internal organs and structures. These cancers can occur in various organs, including the lungs, colon, prostate, and breast, and are characterized by the abnormal growth of cells that have glandular properties, often producing mucus or other secretions.

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community Evolution theory: AGA is your body trying to reduce the risk of prostate cancer by exposing your scalp to more UV

in Research/Science 6 months ago

Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.

community I find it crazy how some people like this bloke have 0 DHT sensitivity. He is on grams of anabolic steroids and has a full, thick head of hair. I wish all of on here had this guys hair genes lol

in Satire 443 upvotes 2 years ago

The conversation is about hair loss and the possibility of maintaining a full head of hair while using anabolic steroids. Some users believe that having good hair genes and taking hair loss protocols can help prevent hair loss while on steroids.

community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

22 upvotes 8 years ago

Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

community Duasteride and breast tissue accumulation.

in Finasteride/Dutasteride 4 upvotes 3 months ago

The user is experiencing breast tissue growth from taking dutasteride and minoxidil, and is considering reducing the dosage or stopping the medication. Suggestions include seeing an endocrinologist, using Raloxifene or Arimidex, and considering topical treatments or surgery if necessary.

community Spanish dermatologist suggests sulforaphane for AGA

in Research/Science 13 upvotes 2 years ago

A Spanish dermatologist suggests sulforaphane for androgenetic alopecia (AGA) due to its potential to remove DHT metabolites, though high dosages are needed. A topical formulation might be possible.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 3 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Treating my DUPA via controlling inflammation

in Treatment 5 upvotes 2 years ago

The user has DUPA and suspects autoimmune activity as a cause. They have tried various treatments including finasteride, minoxidil, dutasteride, pyrilutamide, estrogel, hydrocortisone, and clobetasol, and are now seeking a long-term immunosuppressant.

community Adrogens and Covid-19

in Treatment 7 upvotes 5 years ago

The possible increased risk of severe Covid-19 cases in men due to higher androgen levels, and how taking medications such as finasteride, dutasteride, spironolactone, enzalutamide, or canabidiol might help mitigate the severity of the disease.

community Starting Treatment for CCCA (scarring alopecia)

in Treatment 6 upvotes 2 years ago

A male in his early 20s with CCCA (scarring alopecia) started treatment with Finasteride, Fluocinolone, and Doxycycline. Steroid injections were suggested but not yet done.

community Question about clascoterone acne cream

in Treatment 2 upvotes 1 month ago

Clascoterone cream can be used on the scalp, but it may not be effective due to its dosage. AR antagonists like clascoterone are generally less effective than 5AR inhibitors for hair loss.

community Autoimmune disease and balding

in Update 12 upvotes 2 years ago

A user diagnosed with Crohn's disease is concerned it might contribute to balding. They have been using keto shampoo, finasteride, and oral minoxidil, which improved their hair but not significantly.

community Clinical Trial: Clascoterone (Cortexolone 17A-Propionate)

in Research/Science 24 upvotes 2 years ago

A user is joining a clinical trial for Clascoterone, a drug approved for acne but being tested for hair loss. They previously tried finasteride with limited success and plan to share updates on their experience with the new treatment.

community Dutasteride Mesotherapy in Los Angeles

in Treatment 5 upvotes 3 years ago

The conversation is about seeking recommendations for clinics in Los Angeles that offer dutasteride mesotherapy for hair loss treatment. The user is asking for experiences and suggestions from the community.

community can someone help me identify these pls

in Treatment 6 months ago

The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

community Clascoterone - what we have right now

in Research/Science 23 upvotes 3 months ago

Clascoterone is a topical treatment for androgenetic alopecia, showing modest to moderate hair regrowth, and may be available by 2027-2028. It is considered safer than finasteride, with discussions on its effectiveness compared to RU58841 and pyrilutamide.

community Has anyone tried CB-01-03 aka Clascoterone?

in Research/Science 2 upvotes 3 months ago

Clascoterone, a topical anti-androgen, is generating interest for potentially fewer systemic side effects. Users are curious about its effectiveness and details like concentration and duration of use.

community European release of clascoterone

in Research/Science 13 upvotes 1 month ago

Clascoterone's European release is expected in Q4 2026, with FDA approval anticipated by mid-2027. The discussion includes questions about the approval timeline and potential acceleration due to unmet needs.

community Anagenic is trying to compound Gt20029

in Treatment 56 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

22 upvotes 6 years ago

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community second shed on dutasteride, but a woman

in Finasteride/Dutasteride 2 upvotes 1 year ago

A woman experiencing hormonal hair loss is on dutasteride and bicalutamide, which initially improved her hair, but she is now experiencing a second shedding phase with significant short hair loss. Despite normal hormone levels and no deficiencies, she is unsure if this shedding is normal and seeks advice.

community Scarring Alopecia and NSAIDs?

in Female 4 upvotes 5 years ago

The user suspects scarring alopecia and is exploring NSAIDs and turmeric/pepper for inflammation-related hair loss, having experienced burning and thinning with finasteride and testosterone reduction. They are seeking feedback while unable to afford a dermatologist.

community Losing hairs on aggressive treatment.

in Transgender 2 upvotes 3 weeks ago

The user is experiencing hair loss despite using estradiol, bicalutamide, dutasteride, and topical minoxidil. They stopped minoxidil temporarily, which worsened their condition, and are considering oral minoxidil but are concerned about side effects and cost.

community Fluridil degrades the androgen receptor.

in Research/Science 12 upvotes 1 year ago

Fluridil degrades androgen receptors, which are prevalent in the scalp and other tissues. People with androgenetic alopecia (AGA) may have higher expression of these receptors and 5AR activity in affected scalp areas.

community Connection between finasteride and nafld?

in Research/Science 4 upvotes 1 year ago

Finasteride may affect liver function and cortisol levels, potentially linking it to non-alcoholic fatty liver disease (NAFLD). More research is needed to understand this connection fully.

community Clascoterone 12 months phase 3 result out

in Treatment 45 upvotes 2 months ago

Clascoterone is promising for hair loss, showing 24.5% improvement in satisfaction compared to placebo. Users consider it an alternative to finasteride, with concerns about absorption and side effects.

community Clascoterone full results in July

in Research/Science 13 upvotes 1 month ago

Clascoterone's full trial results are expected by mid-July 2026, but skepticism exists about timely release. Clascoterone is available at 5% from some telehealth companies.

community AGA responded to steroid shots? Biopsy wrong? Please help!

in Female 2 upvotes 2 years ago

A woman with AGA is using spironolactone, dutasteride, finasteride, oral minoxidil, bicalutamide, and anti-androgenic birth control but still experiences worsening hair loss. Steroid shots temporarily stop her hair shedding, leading her to question her biopsy results.

community ghk-cu is potent 5-ar inhibitor?

in Product 10 upvotes 2 years ago

GHK-Cu is a potent inhibitor of the type 1 5-alpha reductase enzyme in hair follicles, which may reduce hair loss without the side effects associated with type 2 5-alpha reductase inhibitors. The user previously experienced side effects with 5-alpha reductase inhibitors and is considering GHK-Cu as an alternative.

community Clascoterone phase 3 results are out!

in Treatment 83 upvotes 6 months ago

Clascoterone phase 3 results show promising improvements in hair count, but concerns about high costs and lack of detailed data remain. Users compare it to existing treatments like Minoxidil and Finasteride, expressing skepticism about its accessibility and effectiveness.