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      community DUPA, Non Responders and Connective Tissue Disorders

      in Research/Science  10 upvotes 9 months ago
      A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.
      “Mature Hairline” or Genuine AGA?

      community “Mature Hairline” or Genuine AGA?

      in Basic Questions  62 upvotes 4 days ago
      A 33-year-old male is experiencing thinning at the temples and hairline, with increased shedding over the past year. The user suspects androgenetic alopecia (AGA) despite AI suggesting a maturing hairline.

      community (17M) Hair loss and Cystic Acnes / Dutasteride

      in Finasteride  109 upvotes 4 months ago
      A 17-year-old is using Finasteride and Minoxidil for hair loss, experiencing hair shedding and cystic acne. They are considering Dutasteride for acne but are concerned about potential side effects on genital development.

      community Dutasteride causing us to have… girl babies?

      in Finasteride/Dutasteride  26 upvotes 2 years ago
      User Kylo313 used dutasteride for 20 years and had two daughters, questioning if dutasteride affects the likelihood of having male vs female children. Replies mostly request hairline photos and discuss anecdotal experiences, with some suggesting correlation doesn't imply causation and that gender determination isn't affected by dutasteride.

      community 29f Female on Dutasteride Progress.

      in Female  14 upvotes 2 years ago
      A 29-year-old woman with genetic hair loss started using 0.5 dutasteride a week ago and has noticed increased shedding, no sexual side effects, and less oily skin. She plans to provide updates and is not concerned about potential birth defects as she doesn't plan to have more children.

      community second shed on dutasteride, but a woman

      in Finasteride/Dutasteride  2 upvotes 10 months ago
      A woman experiencing hormonal hair loss is on dutasteride and bicalutamide, which initially improved her hair, but she is now experiencing a second shedding phase with significant short hair loss. Despite normal hormone levels and no deficiencies, she is unsure if this shedding is normal and seeks advice.

      community Fluridil degrades the androgen receptor.

      in Research/Science  12 upvotes 9 months ago
      Fluridil degrades androgen receptors, which are prevalent in the scalp and other tissues. People with androgenetic alopecia (AGA) may have higher expression of these receptors and 5AR activity in affected scalp areas.

      community Binding affinity of pyrilutamide!

      in Update  170 upvotes 3 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community Dont know what the hell is going on.

      in Chat  6 upvotes 1 year ago
      The user experienced rapid diffuse hair thinning for five years despite no signs of AGA or miniaturization. They tried finasteride and oral minoxidil without success and have checked thyroid, iron, and vitamin D levels.

      community M21 one year progress fin only

      in Progress Pictures  51 upvotes 1 year ago
      A 21-year-old shares their one-year progress using finasteride for hair loss, experiencing initial shedding but eventual regrowth, especially on the crown. They consider switching to dutasteride due to continued hair loss at the front temple and mid-scalp areas.

      community M19 shed after 1yr on dutasteride

      in Finasteride/Dutasteride  23 upvotes 1 year ago
      A 19-year-old male experienced hair shedding after one year on dutasteride and is considering adding topical minoxidil despite scalp itching. Users suggest continuing dutasteride, maintaining a consistent hair routine, and possibly increasing minoxidil dosage.

      community Dutasteride UPDATE (female) *sixth month*

      in Progress Pictures  16 upvotes 3 years ago
      A female user in her mid-20s with androgenetic alopecia and suspected telogene effluvium who has been taking Dutasteride, Spironolactone, Minoxidil, Dermarolling, Ketoconazol shampoo, and Yaz contraception for her hair loss for the past 6 months. She had a small shed during this time that she believes to be stress related.

      community Duasteride and breast tissue accumulation.

      in Finasteride/Dutasteride  1 upvotes 1 month ago
      The user is experiencing breast tissue growth from taking dutasteride and minoxidil, and is considering reducing the dosage or stopping the medication. Suggestions include seeing an endocrinologist, using Raloxifene or Arimidex, and considering topical treatments or surgery if necessary.

      community Diffuse thinning is so brutal.

      in Styling  71 upvotes 2 years ago
      A 25-year-old with AGA experienced hair thinning and dandruff, stabilized with topical finasteride and minoxidil but saw minimal regrowth. They seek advice on styling and consider oral minoxidil and microneedling for denser hair.

      community DHEA, the culprit behind DUPA ? Read this!

      in Research/Science  20 upvotes 2 years ago
      High DHEA levels may contribute to hair loss by increasing DHT in hair follicles, potentially explaining why finasteride is ineffective for some. Treatments like high-dose dutasteride and RU58841 are suggested, but the underlying cause, such as adrenal issues, should be investigated.

      community The Hormonal Profile of MPB/AGA

      in Research/Science  9 upvotes 4 years ago
      Men with early male pattern baldness (MPB) may have hormonal abnormalities similar to those in women with PCOS. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

      community Having AGA as a girl makes me depressed

      in Female  65 upvotes 1 month ago
      A 20-year-old woman with androgenetic alopecia feels depressed about her hair loss, despite using topical minoxidil, spironolactone, and saw palmetto. Suggestions include trying oral minoxidil, higher doses of finasteride or dutasteride, and checking for vitamin deficiencies and heavy metal exposure.

      community AA and Hirsutism but T levels are normal

      in Female  6 upvotes 5 years ago
      27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.