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      community Topical Pyrilutamide - Hormone Panel

      in Treatment  2 upvotes 2 years ago
      The user used 0.5 mL of 0.5 mg of Pyrilutamide for 60 days for hair loss, but didn't notice any hair growth. They shared their hormone panel results and are seeking advice on next steps.

      community Am I crazy or is this recovery?

      in Is this regrowth?  134 upvotes 1 year ago
      The user is experiencing sudden hair loss and is considering micro-needling, low-level light therapy, iron supplements, folihair, and Omega 3. They are hesitant to start finasteride, suspecting the hair loss might be due to telogen effluvium from a past COVID-19 infection.

      community Drastic loss after stabilization for 5 years of DHT blockers, topical minoxidil, nizoral shampoo

      in Update  8 upvotes 1 year ago
      A 27-year-old is experiencing significant hair loss despite using a combination of 0.5mg dutasteride daily, topical minoxidil, nizoral shampoo, and vitamin D optimization, and is now starting zinc supplementation. Suggestions include considering other causes, possibly increasing dutasteride dosage, switching to oral minoxidil, or maintaining the current regimen and reassessing in six months.

      community Androgenic alopecia exclusively on the vertex of the scalp

      in Chat  6 upvotes 2 years ago
      A user experienced androgenic alopecia starting at the vertex without frontal hairline recession and is seeking information on this pattern. Another user noted that vertex or diffuse hair loss is common among men.

      community is this hyper responding? oral fin and min combi pill

      in Progress Pictures  8 upvotes 9 months ago
      A 42-year-old experienced significant hair regrowth after 12 weeks on an oral combination of finasteride (1 mg) and minoxidil (2.5 mg), with noticeable improvements and no side effects. The user is considering continuing the treatment for a year due to the unexpected positive results.

      community Chat is this real? Compound called clascoterone

      in Research/Science  588 upvotes 6 months ago
      Clascoterone shows promising results for hair regrowth in men with androgenetic alopecia, with potential FDA approval by 2026. It acts as a topical androgen receptor blocker, offering a new treatment option with minimal side effects compared to existing treatments like finasteride.

      community Hypertrichosis goals (yes, yes R2M)

      in General  115 upvotes 1 year ago
      The user aims to achieve a hypertrichosis look and has used topical Minoxidil for 20 years, now trying oral Minoxidil in a low dose. They seek alternatives to Minoxidil to avoid side effects.

      community Spironolactone and pregnancy planning

      in Female  2 upvotes 1 year ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

      community I think I’m on to something

       24 upvotes 6 years ago
      The user shared their personal experience with hair loss, hormone imbalances, and treatments including testosterone boosters, natural estrogen blockers, and DHEA. They suggest that low-dose finasteride and natural hormone therapy could reduce hair loss with fewer side effects.

      community Anyone else experiencing scalp inflammation? Get in here!

       5 upvotes 7 years ago
      A user found that taking Zyrtec (Cetirizine) and Advil helped reduce their scalp inflammation and pain, potentially creating a better environment for hair growth. They have not used any other medication for hair loss or scalp issues.

      community Topical bicalutamide vs ru58841

      in Female  1 upvotes 1 year ago
      A user is seeking advice on making a topical bicalutamide solution as an alternative to RU58841 for hair loss, while already using dutasteride and minoxidil. They are considering crushing bicalutamide pills and adding them to their minoxidil.

      community Hairloss is mentally exhausting

      in Chat  24 upvotes 5 years ago
      The conversation is about the mental toll of hair loss and seeking alternatives to finasteride. Suggestions include using minoxidil, considering pumpkin seed oil, and possibly seeking counseling for body dysmorphic disorder.

      community Are these all the anti androgen products?

      in Treatment  6 upvotes 2 years ago
      The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

      community Severe diffuse thinning since 13 years old

      in Treatment  6 upvotes 1 year ago
      A 15-year-old experiencing severe diffuse thinning plans to use minoxidil, dermarolling, and possibly ketoconazole, with hopes to later incorporate finasteride. Concerns about starting finasteride too young and the need for a dermatologist consultation are discussed.

      community Severe diffuse thinning after scalp inflammation – should I keep fighting or just accept it?

      in Finasteride/Dutasteride  4 upvotes 8 months ago
      A 23-year-old experiencing severe diffuse thinning after scalp inflammation is considering finasteride as a last resort after stopping minoxidil and using anti-inflammatory medication. Users suggest that inflammation causes temporary shedding and recommend consulting a dermatologist, with some advocating for finasteride as a reliable treatment option.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.